Table 1 Variables predicting AD in addition to < −1 SD on two episodic memory tests
Block by block | Final model | ||||||
|---|---|---|---|---|---|---|---|
Predictor | Nagelkerke’s R 2 | Odds ratio | Confidence interval | P | Odds ratio | Confidence interval | P |
Block 1: main predictors | 0.422 | ||||||
Age | 1.031 | 1.0, 1.1 | 0.146 | 1.006 | 1.0, 1.1 | 0.812 | |
Education | 0.987 | 0.9, 1.1 | 0.780 | 0.989 | 0.9, 1.1 | 0.830 | |
Sex | 1.131 | 0.7, 2.0 | 0.662 | 1.163 | 0.6, 2.1 | 0.626 | |
Mini-mental state exam | 0.712 | 0.6, 0.8 | <0.001 | 0.763 | 0.6, 0.9 | 0.001 | |
< −1 SD on two tests | 12.845 | 6.7, 24.6 | <0.001 | 8.082 | 3.9, 16.8 | <0.001 | |
Block 2: non-memory tests | 0.439 | ||||||
Category fluency | 0.853 | 0.7, 1.1 | 0.227 | 0.869 | 0.7, 1.1 | 0.314 | |
Boston naming test | 0.944 | 0.9, 1.0 | 0.167 | 0.948 | 0.9, 1.0 | 0.227 | |
Trails B/A ratio | 1.215 | 0.9, 1.6 | 0.130 | 1.142 | 0.9, 1.5 | 0.342 | |
Block 3: biomarkers | 0.490 | ||||||
Apolipoprotein E ε4 | 0.031 | ||||||
Apolipoprotein E ε4 (1 allele) | 1.797 | 1.0, 3.3 | 0.055 | ||||
Apolipoprotein E ε4 (2 alleles) | 2.992 | 1.2, 7.3 | 0.016 | ||||
Total hippocampal volume | 0.081 | 0.0, 12.3 | 0.326 | ||||
Brain parenchymal fraction | 0.000 | 0.0, 27.9 | 0.123 | ||||
White matter hyperintensity | 1.085 | 1.0, 1.2 | 0.121 | ||||
Ventricular cerebrospinal fluid | 1.135 | 0.9, 1.4 | 0.240 | ||||