Fig. 3

Precision of the ADAS-CogIRT methodology: figure showing item-wise and cumulative Fisher information associated with the estimation of (a) memory, (b) language, and (c) praxis impairment. The plot in (d) shows the expected magnitudes of estimation errors associated with different levels of memory, language, and praxis impairment. The superimposed histogram in plot (d) shows the distribution of baseline cognitive impairment in mild-to-moderate Alzheimer’s patients, which have been appropriately scaled for better interpretation. ADAS-CogIRT Alzheimer’s disease assessment scale-Cognitive subscale scoring methodology based on item response theory