| |
Blood AC, %ID/g
|
Heart AC, %ID/g
|
Brain AC, %ID/g
|
Perispinal region AC, %ID/g
|
Dorsal tail vein AC, %ID/g
|
|---|
|
Cetuximab
| | | | | |
|
Perispinal
| | | | | |
|
Rat 1
|
2.06
|
0.39
|
4.05
|
0.06
|
–
|
|
Rat 2
|
0.19
|
0.05
|
0.01
|
17.15
|
–
|
|
Dorsal tail vein
| | | | | |
|
Rat 3
|
5.24
|
1.61
|
0.10
|
–
|
0.46
|
|
Etanercept
| | | | | |
|
Perispinal
| | | | | |
|
Rat 4
|
0.14
|
0.04
|
0.01
|
1.10
|
–
|
|
Rat 5
|
0.10
|
0.03
|
0.01
|
0.93
|
–
|
|
Dorsal tail vein
| | | | | |
|
Rat 6
|
2.98
|
0.91
|
0.08
|
–
|
0.20
|
|
Anakinra
| | | | | |
|
Perispinal
| | | | | |
|
Rat 7
|
0.30
|
0.11
|
0.06
|
10.86
|
–
|
|
Rat 8
|
0.16
|
0.07
|
0.02
|
7.31
|
–
|
|
Dorsal tail vein
| | | | | |
|
Rat 9
|
0.37
|
0.19
|
0.04
|
–
|
0.15
|
-
Abbreviations: AC average concentration, %ID/g percentage injected dose per gram of tissue
