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Defining criteria
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1.
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Perivascular accumulation of abnormal hyperphosphorylated tau within neurons, astrocytes, and/or cell processes in the neocortex
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2.
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Irregular distribution of p-tau–immunoreactive cells and processes at the depths of cerebral sulci
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Supportive criteria
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3.
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Macroscopic abnormalities in the septum pellucidum (cavum, fenestration), disproportionate dilation of the third ventricle or signs of previous brain injury
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4.
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Abnormal tau-immunoreactive neuronal lesions affecting the neocortex predominantly in superficial layers 2 and 3, as opposed to layers 3 and 5 as in AD
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