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Table 3 Pathological criteria used for CTE diagnosis

From: Assessing clinicopathological correlation in chronic traumatic encephalopathy: rationale and methods for the UNITE study

Defining criteria
1. Perivascular accumulation of abnormal hyperphosphorylated tau within neurons, astrocytes, and/or cell processes in the neocortex
2. Irregular distribution of p-tau–immunoreactive cells and processes at the depths of cerebral sulci
Supportive criteria
3. Macroscopic abnormalities in the septum pellucidum (cavum, fenestration), disproportionate dilation of the third ventricle or signs of previous brain injury
4. Abnormal tau-immunoreactive neuronal lesions affecting the neocortex predominantly in superficial layers 2 and 3, as opposed to layers 3 and 5 as in AD
  1. Abbreviations: AD Alzheimer’s disease, CTE chronic traumatic encephalopathy
  2. These criteria are based on previous publications [2, 27] and A.C. McKee