Table 3 Pathological criteria used for CTE diagnosis
Descriptions | |
|---|---|
Defining criteria | |
1. | Perivascular accumulation of abnormal hyperphosphorylated tau within neurons, astrocytes, and/or cell processes in the neocortex |
2. | Irregular distribution of p-tau–immunoreactive cells and processes at the depths of cerebral sulci |
Supportive criteria | |
3. | Macroscopic abnormalities in the septum pellucidum (cavum, fenestration), disproportionate dilation of the third ventricle or signs of previous brain injury |
4. | Abnormal tau-immunoreactive neuronal lesions affecting the neocortex predominantly in superficial layers 2 and 3, as opposed to layers 3 and 5 as in AD |