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Table 2 rBGM comparison between aMCI, naMCI, and CG using SPM8a. Results showing areas of rBGM reduction

From: Brain metabolism and cerebrospinal fluid biomarkers profile of non-amnestic mild cognitive impairment in comparison to amnestic mild cognitive impairment and normal older subjects

  Z score p value Cluster size (number of voxels) Peak voxel coordinates (Talairach)
aMCI × CGb
 Left middle temporal gyrus, BA39 3.51 <0.001 41 −46 −67 20
 Left precuneus, BA31 3.17 <0.001 33 −4 −51 32
 Left precuneus, BA7 3.33 <0.001 15 −2 −63 64
aMCI × naMCIb
 Left temporal lobe 3.62 <0.001 167 −44 −45 2
naMCI × control groupb
 Right inferior frontal gyrus, BA9 3.80 <0.001 34 46 11 29
 Right middle frontal gyrus, BA9 3.40 <0.001 51 34 34 28
 Right middle frontal gyrus, BA8 3.32 <0.001 51 32 29 39
 Right middle gyrus, BA10 3.24 0.001 11 38 45 16
 Left superior occipital gyrus, BA19 3.42 <0.001 41 −42 −72 28
 Left precuneus, BA7 3.20 0.001 32 0 −63 60
 Left parietal lobe, BA7 3.16 0.001 32 −4 −62 70
naMCI × aMCIb
 Right middle frontal gyrus, BA46 3.33 <0.001 19 51 29 26
  1. aResults at the peak voxel level (global analysis, analysis of variance and post-hoc nonpaired t test). SPM8 software from Wellcome Department of Cognitive Neurology (Functional Imaging Laboratory, London, UK)
  2. bUncorrected for multiple comparisons
  3. aMCI amnestic mild cognitive impairment, BA Broadmann area, CG control group, naMCI nonamnestic mild cognitive impairment, rBGM regional brain glucose metabolism