| |
CG (n = 30)
|
aMCI (n = 33)
|
naMCI (n = 32)
|
p value (two-tailed)
|
|---|
| | | |
Multiple comparison
|
|---|
|
Age (years)a
|
69.5 (6.4)
|
72.6 (5.5)
|
69.8 (5.8)
|
0.065
|
|
Gender (female/male)b
|
24/6
|
20/13
|
23/9
|
0.23
|
|
Education (years)a
|
12.9 (4.9)
|
9.2 (4.0)
|
11.8 (4.3)
|
0.018
|
|
CG × aMCI
|
|
(p = 0.017)
|
|
GDSc
|
–
|
1.5 (1.3)
|
1 (1.4)
|
0.113
|
|
GAIc
|
–
|
6.6 (4.3)
|
5.1 (4.1)
|
0.181
|
|
Hypertensionb
|
–
|
19 (57 %)
|
15 (46 %)
|
0.388
|
|
Diabetes mellitusb
|
–
|
7 (21 %)
|
3 (9 %)
|
0.186
|
|
MMSEa
|
29.0 (1.0)
|
27.6 (1.5)
|
27.8 (1.9)
|
0.000
|
|
CG × aMCI and naMCI
|
|
(p <0.003)
|
|
CSF Aβc,d
|
–
|
704 (248)
|
918 (430)
|
0.044
|
|
CSF tauc,d
|
–
|
258 (125)
|
247 (110)
|
0.84
|
|
CSF p-tauc,d
|
–
|
44 (12)
|
43 (14)
|
0.97
|
|
CSF p-tau/Aβ proteind
| |
0.07 (0.05)
|
0.06 (0.04)
|
0.13
|
|
WMH visual scaleb [24]
|
0: 06 (20 %)
|
0: 04 (12 %)
|
0: 04 (13 %)
|
0.525
|
| |
I: 13 (43 %)
|
I: 16 (49 %)
|
I: 18 (56 %)
|
| |
II: 08 (27 %)
|
II: 09 (27 %)
|
II: 10 (31 %)
|
| |
III: 03 (10 %)
|
III: 04 (12 %)
|
III: 0 (0 %)
|
- Data presented as mean (standard deviation)
-
aAnalysis of variance (post-hoc test: Bonferroni)
-
bChi-square test
-
c
t test
-
dSubsample of 54 subjects (26 naMCI patients and 28 aMCI patients), Mann–Whitney test (not normally distributed)
-
aMCI amnestic mild cognitive impairment, Aβ amyloid beta, CG control group, CSF cerebrospinal fluid, GAI Geriatric Anxiety Scale, GDS Geriatric Depression Scale (15 items), MMSE Mini-Mental State Examination, naMCI nonamnestic mild cognitive impairment, p-tau phosphorylated-tau, WMH white matter hyperintensities
