Fig. 2
From: Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans
The effects of ibuprofen and GSM-1 on CSF and plasma Aβ levels in cynomolgus monkeys. Cerebrospinal fluid (CSF) and plasma samples were collected at indicated time points and amyloid beta-peptide (Aβ) levels were measured. Levels of total Aβ (a), Aβ42 (b) and Aβ38 (c) were compared in CSF samples. Ratios of Aβ42 to total Aβ (d) and Aβ38 to total Aβ (e) were compared in CSF samples and ratios of Aβ42/Aβ40 were compared in plasma samples (f). The levels and ratios were normalized to baseline (time 0 or before drug dosing) and shown as percentages of baseline. Seven monkeys were used in the no-treatment group. However, the catheters in two animals did not maintain patency during the study period. Therefore, fewer animals received the single dose of GSM-1 (n = 6) or ibuprofen (n = 5). Results are presented as mean ± SEM; *p < 0.05, **p < 0.001. GSM gamma-secretase modulator