An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter

Table 2 In-dwelling catheter studies

Sponsor	Study	Subjects (n)	Study site	Gender (male/female)	Age (mean (SD))	CSF sampling volume/frequency
AbbVie	A1	6	CCT	6/10	38.2 (9)	8 ml approximately every 2 hours for 24 hours
	A2	22	CCT	17/5	68.5 (7.2)	8 ml approximately every 4 hours for 24 hours
	A3	8	CCT	8/0	35.3 (8.1)	8 ml approximately every 1 hour for 24 hours; participants repeated study
BMS	B1	10	CCT	10/0	31.6 (6.5)	7 ml every hour for 48 hours
Lilly	L6	6	LCRU		60.8 (8.4)	0.1 ml every 1 minute
	L7	7	WU	7/0	34 (7)	6 ml every hour for 36 hours
	L8	10	PAREXEL		34.6 (8)	Volume not obtained; every 1 hour for 10 hours; every 2 hours for 26 hours
	L5-B	2	LCRU		52.7 (4)	Volume not obtained; every 1 hour for 10 hours
Merck	M1	6	VU	3/3	37.3 (4.6)	0.5 ml every 5 minutes
	M2	3	CCT	3/0	26 (7)	6 ml every 1 hour for 8 hours; every 2 hours for 4 hours; after the last 4 hours
	M3	6	CCT	4/2	54.3 (7.9)	4.5 ml every 1 hour for 16 hours; every 2 hours for 10 hours
	M4	9	CCT	6/2^a	52 (7.8)^a	8 ml every 1 hour for 14 hours; every 2 hours for 12 hours
	M5	6	CCT	6/0	38.3 (6)	6 ml every 1 hour for 14 hours; every 2 hours for 12 hours
	M6	4	SGS	3/1	56.5 (10)	Same as M5
	M7	4	SGS	2/2	46.5 (10)	Same as M5
RUMC	R1	12	RUMC		70.3 (7.5)	6 ml every 1 hour for 36 hours
WU	W1	57	WU	29/28	60.7 (19)	6 ml every 1 hour for 36 hours
Total		178

^aMissing gender and age for one participant
AbbVie AbbVie Inc. (North Chicago, IL, USA), AD Alzheimer’s disease, BMS Bristol-Myers Squibb (New York, NY, USA), CCT California Clinical Trials Medical Group (Glendale, CA, USA), CSF cerebrospinal fluid, LCRU Lilly Clinical Research Unit (Indianapolis, IN, USA), Lilly Eli Lilly and Company (Indianapolis, IN, USA), Merck Merck Research Labs (Merck and Company (Kenilworth, NJ, USA); Boston, MA, USA; Upper Gwynedd, PA, USA), Parexel PAREXEL International Early Phase (Los Angeles, CA, USA), RUMC Radboud University Medical Center (Nijmegen, the Netherlands), SD standard deviation, SGS Clinical Research (Antwerpen, Belgium), VU Vanderbilt University (Nashville, TN, USA), WU Washington University (St Louis, MO, USA)

ISSN: 1758-9193