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Table 2 In-dwelling catheter studies

From: An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter

Sponsor Study Subjects (n) Study site Gender (male/female) Age (mean (SD)) CSF sampling volume/frequency
AbbVie A1 6 CCT 6/10 38.2 (9) 8 ml approximately every 2 hours for 24 hours
A2 22 CCT 17/5 68.5 (7.2) 8 ml approximately every 4 hours for 24 hours
A3 8 CCT 8/0 35.3 (8.1) 8 ml approximately every 1 hour for 24 hours; participants repeated study
BMS B1 10 CCT 10/0 31.6 (6.5) 7 ml every hour for 48 hours
Lilly L6 6 LCRU   60.8 (8.4) 0.1 ml every 1 minute
L7 7 WU 7/0 34 (7) 6 ml every hour for 36 hours
L8 10 PAREXEL   34.6 (8) Volume not obtained; every 1 hour for 10 hours; every 2 hours for 26 hours
L5-B 2 LCRU   52.7 (4) Volume not obtained; every 1 hour for 10 hours
Merck M1 6 VU 3/3 37.3 (4.6) 0.5 ml every 5 minutes
M2 3 CCT 3/0 26 (7) 6 ml every 1 hour for 8 hours; every 2 hours for 4 hours; after the last 4 hours
M3 6 CCT 4/2 54.3 (7.9) 4.5 ml every 1 hour for 16 hours; every 2 hours for 10 hours
M4 9 CCT 6/2a 52 (7.8)a 8 ml every 1 hour for 14 hours; every 2 hours for 12 hours
M5 6 CCT 6/0 38.3 (6) 6 ml every 1 hour for 14 hours; every 2 hours for 12 hours
M6 4 SGS 3/1 56.5 (10) Same as M5
M7 4 SGS 2/2 46.5 (10) Same as M5
RUMC R1 12 RUMC   70.3 (7.5) 6 ml every 1 hour for 36 hours
WU W1 57 WU 29/28 60.7 (19) 6 ml every 1 hour for 36 hours
Total   178     
  1. aMissing gender and age for one participant
  2. AbbVie AbbVie Inc. (North Chicago, IL, USA), AD Alzheimer’s disease, BMS Bristol-Myers Squibb (New York, NY, USA), CCT California Clinical Trials Medical Group (Glendale, CA, USA), CSF cerebrospinal fluid, LCRU Lilly Clinical Research Unit (Indianapolis, IN, USA), Lilly Eli Lilly and Company (Indianapolis, IN, USA), Merck Merck Research Labs (Merck and Company (Kenilworth, NJ, USA); Boston, MA, USA; Upper Gwynedd, PA, USA), Parexel PAREXEL International Early Phase (Los Angeles, CA, USA), RUMC Radboud University Medical Center (Nijmegen, the Netherlands), SD standard deviation, SGS Clinical Research (Antwerpen, Belgium), VU Vanderbilt University (Nashville, TN, USA), WU Washington University (St Louis, MO, USA)