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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter

Fig. 4

Diurnal oscillation of Aβ peptides in participants from three different study cohorts. Data presented as mean-adjusted average Aβ levels of the group over time of day for all subjects. Data from AbbVie Inc. for (a) Aβ40 and (b) Aβ42, from Bristol-Myers Squibb (BMS) for (c) Aβ40 and (d) Aβ42, and from Eli Lilly and Company for (e) Aβ40 and (f) Aβ42. Mesor-to-peak amplitudes of diurnal fluctuation of Aβ40 were 4.61 % (AbbVie), –6.52 % (BMS), and –4.90 % (Lilly). Mesor-to-peak amplitudes of diurnal fluctuation of Aβ42 were 4.29 % (AbbVie), –7.01 % (BMS), and –5.34 % (Lilly). The cosine transformation for all datasets were significantly different from a straight line except for Aβ42 from the AbbVie studies (p = 0.06). CI confidence interval

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Alzheimer's Research & Therapy

ISSN: 1758-9193