Skip to main content
Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter

Fig. 3

Diurnal oscillation of Aβ peptides in participants from two different study cohorts. Data presented as mean-adjusted average Aβ levels of the group over time of day for all subjects. Data from Merck and Company for (a) Aβ40 and (b) Aβ42, and data from Washington University for (c) Aβ40 and (d) Aβ42. Mesor-to-peak amplitudes of diurnal fluctuation of Aβ40 were 5.48 % for Merck and 4.91 % for Washington University. Mesor-to-peak amplitudes of diurnal fluctuation of Aβ42 were 4.87 % for Merck and 4.26 % for Washington University. The cosine transformation for all datasets was significantly different from a straight line (all p <0.0001). CI confidence interval

Back to article page