TY - JOUR AU - Price, J. L. AU - McKeel, D. W. AU - Buckles, V. D. PY - 2009 DA - 2009// TI - Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease JO - Neurobiol Aging. VL - 30 UR - https://doi.org/10.1016/j.neurobiolaging.2009.04.002 DO - 10.1016/j.neurobiolaging.2009.04.002 ID - Price2009 ER - TY - JOUR AU - Villemagne, V. L. AU - Pike, K. E. AU - Chetelat, G. PY - 2011 DA - 2011// TI - Longitudinal assessment of Abeta and cognition in aging and Alzheimer disease JO - Ann Neurol. VL - 69 UR - https://doi.org/10.1002/ana.22248 DO - 10.1002/ana.22248 ID - Villemagne2011 ER - TY - JOUR AU - Sperling, R. A. AU - Aisen, P. S. AU - Beckett, L. A. PY - 2011 DA - 2011// TI - Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging–Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease JO - Alzheimers Dement. VL - 7 UR - https://doi.org/10.1016/j.jalz.2011.03.003 DO - 10.1016/j.jalz.2011.03.003 ID - Sperling2011 ER - TY - JOUR AU - Bateman, R. J. AU - Xiong, C. AU - Benzinger, T. L. PY - 2012 DA - 2012// TI - Clinical and biomarker changes in dominantly inherited Alzheimer’s disease JO - N Engl J Med. VL - 367 UR - https://doi.org/10.1056/NEJMoa1202753 DO - 10.1056/NEJMoa1202753 ID - Bateman2012 ER - TY - STD TI - Sperling RA, Jack Jr CR, Aisen PS. Testing the right target and right drug at the right stage. Sci Transl Med. 2011;3:111cm133. ID - ref5 ER - TY - JOUR AU - Cummings, J. L. AU - Doody, R. AU - Clark, C. PY - 2007 DA - 2007// TI - Disease-modifying therapies for Alzheimer disease: challenges to early intervention JO - Neurology. VL - 69 UR - https://doi.org/10.1212/01.wnl.0000295996.54210.69 DO - 10.1212/01.wnl.0000295996.54210.69 ID - Cummings2007 ER - TY - JOUR AU - Bateman, R. J. AU - Aisen, P. S. AU - Strooper, B. PY - 2011 DA - 2011// TI - Autosomal-dominant Alzheimer’s disease: a review and proposal for the prevention of Alzheimer’s disease JO - Alzheimers Res Ther. VL - 2 ID - Bateman2011 ER - TY - JOUR AU - Andrieu, S. AU - Coley, N. AU - Aisen, P. PY - 2009 DA - 2009// TI - Methodological issues in primary prevention trials for neurodegenerative dementia JO - J Alzheimers Dis. VL - 16 ID - Andrieu2009 ER - TY - JOUR AU - Thal, L. J. PY - 2006 DA - 2006// TI - Prevention of Alzheimer disease JO - Alzheimer Dis Assoc Disord. VL - 20 UR - https://doi.org/10.1097/00002093-200607001-00015 DO - 10.1097/00002093-200607001-00015 ID - Thal2006 ER - TY - JOUR AU - Campion, D. AU - Dumanchin, C. AU - Hannequin, D. PY - 1999 DA - 1999// TI - Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum JO - Am J Hum Genet. VL - 65 UR - https://doi.org/10.1086/302553 DO - 10.1086/302553 ID - Campion1999 ER - TY - JOUR AU - Ringman, J. M. PY - 2005 DA - 2005// TI - What the study of persons at risk for familial Alzheimer’s disease can tell us about the earliest stages of the disorder: a review JO - J Geriatr Psychiatry Neurol. VL - 18 UR - https://doi.org/10.1177/0891988705281878 DO - 10.1177/0891988705281878 ID - Ringman2005 ER - TY - JOUR AU - Mullan, M. AU - Houlden, H. AU - Crawford, F. PY - 1993 DA - 1993// TI - Age of onset in familial early onset Alzheimer’s disease correlates with genetic aetiology JO - Am J Med Genet. VL - 48 UR - https://doi.org/10.1002/ajmg.1320480303 DO - 10.1002/ajmg.1320480303 ID - Mullan1993 ER - TY - JOUR AU - Bird, T. D. AU - Levy-Lahad, E. AU - Poorkaj, P. PY - 1996 DA - 1996// TI - Wide range in age of onset for chromosome 1-related familial Alzheimer’s disease JO - Ann Neurol. VL - 40 UR - https://doi.org/10.1002/ana.410400619 DO - 10.1002/ana.410400619 ID - Bird1996 ER - TY - JOUR AU - Ryman, D. C. AU - Acosta-Baena, N. AU - Aisen, P. S. PY - 2014 DA - 2014// TI - Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis JO - Neurology. VL - 83 UR - https://doi.org/10.1212/WNL.0000000000000596 DO - 10.1212/WNL.0000000000000596 ID - Ryman2014 ER - TY - JOUR AU - Ringman, J. M. AU - Younkin, S. G. AU - Pratico, D. PY - 2008 DA - 2008// TI - Biochemical markers in persons with preclinical familial Alzheimer disease JO - Neurology. VL - 71 UR - https://doi.org/10.1212/01.wnl.0000303973.71803.81 DO - 10.1212/01.wnl.0000303973.71803.81 ID - Ringman2008 ER - TY - JOUR AU - Moulder, K. L. AU - Snider, B. J. AU - Mills, S. L. PY - 2013 DA - 2013// TI - Dominantly Inherited Alzheimer Network: facilitating research and clinical trials JO - Alzheimers Res Ther. VL - 5 UR - https://doi.org/10.1186/alzrt213 DO - 10.1186/alzrt213 ID - Moulder2013 ER - TY - JOUR AU - Ringman, J. M. AU - Grill, J. AU - Rodriguez-Agudelo, Y. PY - 2009 DA - 2009// TI - Commentary on “a roadmap for the prevention of dementia II: Leon Thal Symposium 2008”. Prevention trials in persons at risk for dominantly inherited Alzheimer’s disease: opportunities and challenges JO - Alzheimers Dement VL - 5 UR - https://doi.org/10.1016/j.jalz.2008.12.002 DO - 10.1016/j.jalz.2008.12.002 ID - Ringman2009 ER - TY - JOUR AU - Steinbart, E. J. AU - Smith, C. O. AU - Poorkaj, P. PY - 2001 DA - 2001// TI - Impact of DNA testing for early-onset familial Alzheimer disease and frontotemporal dementia JO - Arch Neurol. VL - 58 UR - https://doi.org/10.1001/archneur.58.11.1828 DO - 10.1001/archneur.58.11.1828 ID - Steinbart2001 ER - TY - JOUR AU - Morris, J. C. AU - Aisen, P. S. AU - Bateman, R. J. PY - 2012 DA - 2012// TI - Developing an international network for Alzheimer research: the Dominantly Inherited Alzheimer Network JO - Clin Investig. VL - 2 UR - https://doi.org/10.4155/cli.12.93 DO - 10.4155/cli.12.93 ID - Morris2012 ER - TY - JOUR AU - Hooper, M. AU - Grill, J. D. AU - Rodriguez-Agudelo, Y. PY - 2013 DA - 2013// TI - The impact of the availability of prevention studies on the desire to undergo predictive testing in persons at risk for autosomal dominant Alzheimer’s disease JO - Contemp Clin Trials. VL - 36 UR - https://doi.org/10.1016/j.cct.2013.07.006 DO - 10.1016/j.cct.2013.07.006 ID - Hooper2013 ER - TY - JOUR AU - Grill, J. D. AU - Karlawish, J. PY - 2010 DA - 2010// TI - Addressing the challenges to successful recruitment and retention in Alzheimer’s disease clinical trials JO - Alzheimers Res Ther. VL - 2 UR - https://doi.org/10.1186/alzrt58 DO - 10.1186/alzrt58 ID - Grill2010 ER - TY - STD TI - Dominantly Inherited Alzheimer’s Network Trials Unit. www.DIAN-TU.org. Accessed date 03/01/2015. UR - http://www.dian-tu.org ID - ref22 ER - TY - JOUR AU - Mills, S. M. AU - Mallmann, J. AU - Santacruz, A. M. PY - 2013 DA - 2013// TI - Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial JO - Rev Neurol. VL - 169 UR - https://doi.org/10.1016/j.neurol.2013.07.017 DO - 10.1016/j.neurol.2013.07.017 ID - Mills2013 ER - TY - JOUR AU - Bird, T. D. PY - 1999 DA - 1999// TI - Risks and benefits of DNA testing for neurogenetic disorders JO - Semin Neurol. VL - 19 UR - https://doi.org/10.1055/s-2008-1040841 DO - 10.1055/s-2008-1040841 ID - Bird1999 ER - TY - JOUR AU - Lennox, A. AU - Karlinsky, H. AU - Meschino, W. PY - 1994 DA - 1994// TI - Molecular genetic predictive testing for Alzheimer’s disease: deliberations and preliminary recommendations JO - Alzheimer Dis Assoc Disord. VL - 8 UR - https://doi.org/10.1097/00002093-199408020-00009 DO - 10.1097/00002093-199408020-00009 ID - Lennox1994 ER - TY - JOUR AU - Babul, R. AU - Adam, S. AU - Kremer, B. PY - 1993 DA - 1993// TI - Attitudes toward direct predictive testing for the Huntington disease gene. Relevance for other adult-onset disorders. The Canadian Collaborative Group on Predictive Testing for Huntington Disease JO - JAMA VL - 270 UR - https://doi.org/10.1001/jama.1993.03510190077030 DO - 10.1001/jama.1993.03510190077030 ID - Babul1993 ER - TY - JOUR AU - Bird, T. D. AU - Bennett, R. L. AU - Lipe, H. P. PY - 1993 DA - 1993// TI - The consequences of testing for Huntington’s disease JO - N Engl J Med. VL - 328 ID - Bird1993 ER - TY - JOUR AU - Marcheco-Teruel, B. AU - Fuentes-Smith, E. PY - 2009 DA - 2009// TI - Attitudes and knowledge about genetic testing before and after finding the disease-causing mutation among individuals at high risk for familial, early-onset Alzheimer’s disease JO - Genet Test Mol Biomarkers. VL - 13 UR - https://doi.org/10.1089/gtmb.2008.0047 DO - 10.1089/gtmb.2008.0047 ID - Marcheco-Teruel2009 ER - TY - JOUR AU - Roberts, J. S. AU - Ostergren, J. PY - 2013 DA - 2013// TI - Direct-to-consumer genetic testing and personal genomics services: a review of recent empirical studies JO - Curr Genet Med Rep. VL - 1 UR - https://doi.org/10.1007/s40142-013-0018-2 DO - 10.1007/s40142-013-0018-2 ID - Roberts2013 ER - TY - JOUR AU - Mouchawar, J. AU - Hensley-Alford, S. AU - Laurion, S. PY - 2005 DA - 2005// TI - Impact of direct-to-consumer advertising for hereditary breast cancer testing on genetic services at a managed care organization: a naturally-occurring experiment JO - Genet Med. VL - 7 UR - https://doi.org/10.1097/01.GIM.0000156526.16967.7A DO - 10.1097/01.GIM.0000156526.16967.7A ID - Mouchawar2005 ER - TY - JOUR AU - Dahodwala, N. AU - Connolly, J. AU - Farmer, J. PY - 2007 DA - 2007// TI - Interest in predictive testing for Parkinson’s disease: impact of neuroprotective therapy JO - Parkinsonism Relat Disord. VL - 13 UR - https://doi.org/10.1016/j.parkreldis.2007.02.010 DO - 10.1016/j.parkreldis.2007.02.010 ID - Dahodwala2007 ER - TY - JOUR AU - Hedera, P. PY - 2001 DA - 2001// TI - Ethical principles and pitfalls of genetic testing for dementia JO - J Geriatr Psychiatry Neurol. VL - 14 UR - https://doi.org/10.1177/089198870101400406 DO - 10.1177/089198870101400406 ID - Hedera2001 ER - TY - JOUR AU - Rosas, H. D. AU - Doros, G. AU - Gevorkian, S. PY - 2014 DA - 2014// TI - PRECREST: a phase II prevention and biomarker trial of creatine in at-risk Huntington disease JO - Neurology. VL - 82 UR - https://doi.org/10.1212/WNL.0000000000000187 DO - 10.1212/WNL.0000000000000187 ID - Rosas2014 ER - TY - BOOK AU - Kim, S. Y. PY - 2015 DA - 2015// TI - Karlawish J and Berkman BE PB - Ethics of genetic and biomarker test disclosures in neurodegenerative disease prevention trials CY - Neurology ID - Kim2015 ER - TY - STD TI - The Belmont Report: ethical principles and guidelines for the protection of human subjects of research. US Government Printing Office. IRB. 1978. ID - ref35 ER - TY - JOUR AU - Horng, S. AU - Grady, C. PY - 2003 DA - 2003// TI - Misunderstanding in clinical research: distinguishing therapeutic misconception, therapeutic misestimation, and therapeutic optimism JO - Irb. VL - 25 UR - https://doi.org/10.2307/3564408 DO - 10.2307/3564408 ID - Horng2003 ER -