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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Unraveling the potential co-contributions of cerebral small vessel vasculopathy to the pathogenesis of Alzheimer’s dementia

Fig. 1

Effects of apolipoprotein E (apoE) ε4 on amyloid-beta (Aβ) metabolism and deposition. apoE may facilitate cellular uptake of Aβ by the endocytosis of apoE-containing lipoprotein particles bound to soluble Aβ (yellow circles), or via binding of this apoE-Aβ complex (mauve-blue circles) to extracellular heparin sulfate proteoglycans (HSPG). Alternatively, apoE may impair Aβ clearance by slowing the transport of Aβ across the blood–brain barrier [1]. LDLR, low-density lipoprotein receptor; LRP, lipoprotein receptor-related protein; PgP, permeability-glycoprotein. Reproduced with permission from Elsevier [1]

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Alzheimer's Research & Therapy

ISSN: 1758-9193