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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Diffusion imaging changes in grey matter in Alzheimer’s disease: a potential marker of early neurodegeneration

Fig. 2

A graphical illustration of the sequence of biomarker changes that are thought to occur in Alzheimer's disease prior to the clinical manifestation of dementia (adapted from the model proposed by Jack et al. [55]). An additional curve has been added (in orange) to represent where microstructural brain changes (the earliest of which are likely to occur in the grey matter) are predicted to lie in the overall sequence. The black arrows show how the use of magnetic resonance imaging to detect diffusivity changes in grey matter may allow significantly earlier detection of neurodegenerative change than is possible with conventional (macro)structural imaging methods. Aβ, amyloid β; MCI, mild cognitive impairment

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