Table 3 Associations of baseline and 5-year FPG and HbA1c with 12-year cognitive function in non-diabetic participants stratified by sex
Speed | Memory | Verbal | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Males | Females | Males | Females | Males | Females | |||||||||||||
β | (SE) | n | β | (SE) | n | β | (SE) | n | β | (SE) | n | β | (SE) | n | β | (SE) | n | |
HbA1c, 25–59 years | ||||||||||||||||||
Baseline | –1.52 | (1.06) | 1192 | 0.63 | (0.95) | 1541 | –0.56* | (0.26) | 1188 | –0.20 | (0.25) | 1534 | –1.60* | (0.67) | 1196 | –0.93 | (0.55) | 1544 |
5 years | –1.55 | (1.07) | 1165 | 1.30 | (0.92) | 1501 | –0.91** | (0.26) | 1161 | –0.13 | (0.24) | 1493 | –1.58* | (0.66) | 1169 | –0.50 | (0.53) | 1504 |
12 years | –1.61* | (0.68) | 1181 | 0.19 | (0.71) | 1526 | –0.24 | (0.17) | 1177 | 0.35 | (0.19) | 1518 | –0.83 | (0.43) | 1185 | –0.01 | (0.41) | 1529 |
HbA1c, 60–85 years | ||||||||||||||||||
Baseline | –0.05 | (2.11) | 260 | –4.82 | (2.47) | 301 | –0.29 | (0.49) | 262 | –0.36 | (0.54) | 299 | 0.00 | (1.64) | 265 | –3.32 | (1.91) | 304 |
5 years | 2.15 | (2.10) | 251 | –1.85 | (2.53) | 292 | 0.19 | (0.49) | 253 | –0.42 | (0.55) | 290 | 1.17 | (1.64) | 256 | –0.63 | (1.88) | 295 |
12 years | 0.59 | (1.62) | 259 | –1.62 | (1.83) | 291 | 0.24 | (0.37) | 260 | –0.48 | (0.41) | 291 | –0.19 | (1.25) | 263 | –0.31 | (1.42) | 294 |
FPG, 25–59 years | ||||||||||||||||||
Baseline | –1.23* | (0.54) | 1202 | 0.97 | (0.54) | 1556 | –0.08 | (0.13) | 1198 | 0.02 | (0.14) | 1549 | –0.43 | (0.35) | 1206 | 0.35 | (0.32) | 1559 |
5 years | –1.33* | (0.53) | 1165 | 0.59 | (0.47) | 1501 | 0.02 | (0.13) | 1161 | –0.09 | (0.13) | 1493 | –0.18 | (0.33) | 1169 | 0.10 | (0.27) | 1504 |
12 years | –0.73 | (0.38) | 1182 | 0.27 | (0.36) | 1528 | 0.07 | (0.09) | 1178 | 0.10 | (0.10) | 1520 | –0.14 | (0.24) | 1186 | 0.09 | (0.21) | 1531 |
FPG, 60–85 years | ||||||||||||||||||
Baseline | 1.40 | (1.12) | 262 | –1.75 | (1.27) | 301 | 0.23 | (0.26) | 264 | –0.30 | (0.27) | 299 | –0.58 | (0.87) | 267 | 0.14 | (0.98) | 304 |
5 years | 0.13 | (0.89) | 251 | –0.89 | (1.16) | 292 | –0.15 | (0.20) | 253 | –0.31 | (0.25) | 290 | 0.31 | (0.69) | 256 | –0.31 | (0.86) | 256 |
12 years | 1.28 | (0.89) | 259 | –1.62 | (0.87) | 291 | 0.24 | (0.20) | 260 | –0.08 | (0.19) | 291 | –0.19 | (0.69) | 263 | –0.53 | (0.68) | 294 |