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Table 1 Summary of methods to analyze neuronal properties

From: Connectivity and circuitry in a dish versus in a brain

Method of study

Single cell resolution

Allowing the recording of multiple single cell signals

Possibility to study intact systems

Analysis of brain circuitry

Possibility to manipulate the experimental conditions (that is, drug concentration)

Difficulty in performing the experiment/time cost

Possibility to study synaptic events

Possibility to analyze sensory responses

Invasivity

Cost

In vitro intracellular recording

+

+

+

+

Intracellular recording on acute brain slices

+

+

+

+

+

Extracellular recording of local field potential

+

Multi-electrode array recording

+

+

+

+

In vivo recording

+

+

+

+

Calcium imaging

+

+

+

+

Optogenetic

+

+

+

+

+

+

+

+

+

+

Vesicle cycling

+

+

+

+

  1. Different aspects are taken into consideration for the methods described (marked + or – depending on the existence of the characteristic described)