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Table 1 Summary of methods to analyze neuronal properties

From: Connectivity and circuitry in a dish versus in a brain

Method of study Single cell resolution Allowing the recording of multiple single cell signals Possibility to study intact systems Analysis of brain circuitry Possibility to manipulate the experimental conditions (that is, drug concentration) Difficulty in performing the experiment/time cost Possibility to study synaptic events Possibility to analyze sensory responses Invasivity Cost
In vitro intracellular recording + + + +
Intracellular recording on acute brain slices + + + + +
Extracellular recording of local field potential +
Multi-electrode array recording + + + +
In vivo recording + + + +
Calcium imaging + + + +
Optogenetic + + + + + + + + + +
Vesicle cycling + + + +
  1. Different aspects are taken into consideration for the methods described (marked + or – depending on the existence of the characteristic described)