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Table 2 Baseline characteristics by geographic region

From: Alzheimer’s disease progression by geographical region in a clinical trial setting

  North America Western Europe/Israel South America Eastern Europe/Russia Japan Asia Australia/South Africa Overall
( n = 832) ( n = 412) ( n = 196) ( n = 195) ( n = 191) ( n = 169) ( n = 84) ( N = 2,079)
Study population with mild AD 547 (66%) 265 (64%) 114 (58%) 106 (54%) 132 (69%) 71 (42%) 57 (68%) 1,292 (62%)
Mean (SD) age (years) 75.0 (8.1) 71.6 (7.7) 74.6 (8.0) 70.9 (7.7) 73.1 (7.7) 72.2 (7.7) 73.0 (7.1) 73.4 (8.0)
Mean (SD) education (years) 14.0 (3.1) 11. 2 (4.2) 9.1 (4.5) 11.8 (3.7) 11. 8 (2.8) 9.6 (4.7) 12.2 (3.4) 12.1 (4.1)
Male 381 (45.8%) 205 (49.8%) 66 (33.7%) 70 (35.9%) 73 (38.2%) 68 (40.2%) 38 (45.2%) 901 (43.3%)
AChEI and/or memantine 736 (88.5%) 387 (93.9%) 167 (85.2%) 145 (74.4%) 173 (90.6%) 139 (82.2%) 66 (78.6%) 1,813 (87.2%)
APOE ε4 carriers 481 (63.0%) 218 (65.7%) 96 (51.1%) 90 (51.4%) 98 (53.0%) 39 (42.4%) 51 (61.4%) 1,073 (59.0%)
Mean (SD) baseline scores         
 ADAS-cog11 21.81 (9.01) 22.97 (9.18) 24.20 (8.75) 27.69 (11.13) 21.37 (6.80) 24.72 (7.72) 21.89 (9.51) 23.02 (9.16)
 ADCS-ADL 62.68 (11.66) 59.34 (13.62) 53.72 (14.17) 49.51 (16.91) 60.45 (11.16) 57.02 (4.80) 59.62 (13.04) 59.16 (13.76)
 MMSE 21.08 (3.67) 21.10 (3.56) 20.37 (3.07) 20.19 (3.15) 20.75 (3.10) 19.49 (3.57) 20.86 (3.49) 20.77 (3.51)
 CDR-SB 5.08 (2.48) 5.41 (2.70) 6.19 (2.74) 7.16 (3.34) 4.95 (2.66) 4.64 (2.53) 5.38 (2.32) 5.41 (2.74)
 NPI 9.21 (10.94) 11.03 (11.73) 12.34 (12.82) 11.24 (11.86) 6.70 (8.69) 7.62 (8.68) 12.13 (10.80) 9.81 (11.13)
  1. Data presented as number (%) or mean (standard deviation). AChEI, acetylcholinesterase inhibitor; AD, Alzheimer’s disease; ADAS-cog11, 11-item Alzheimer’s disease Assessment Scale – cognitive subscale; ADCS-ADL, Alzheimer’s disease Cooperative Study – Activities of Daily Living; APOE, apolipoprotein E; CDR-SB, Clinical Dementia Rating Scale sum of boxes; MMSE, Mini-Mental State Examination; NPI, Neuropsychiatric Inventory; SD, standard deviation.