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Table 2 Baseline characteristics by geographic region

From: Alzheimer’s disease progression by geographical region in a clinical trial setting

 

North America

Western Europe/Israel

South America

Eastern Europe/Russia

Japan

Asia

Australia/South Africa

Overall

( n = 832)

( n = 412)

( n = 196)

( n = 195)

( n = 191)

( n = 169)

( n = 84)

( N = 2,079)

Study population with mild AD

547 (66%)

265 (64%)

114 (58%)

106 (54%)

132 (69%)

71 (42%)

57 (68%)

1,292 (62%)

Mean (SD) age (years)

75.0 (8.1)

71.6 (7.7)

74.6 (8.0)

70.9 (7.7)

73.1 (7.7)

72.2 (7.7)

73.0 (7.1)

73.4 (8.0)

Mean (SD) education (years)

14.0 (3.1)

11. 2 (4.2)

9.1 (4.5)

11.8 (3.7)

11. 8 (2.8)

9.6 (4.7)

12.2 (3.4)

12.1 (4.1)

Male

381 (45.8%)

205 (49.8%)

66 (33.7%)

70 (35.9%)

73 (38.2%)

68 (40.2%)

38 (45.2%)

901 (43.3%)

AChEI and/or memantine

736 (88.5%)

387 (93.9%)

167 (85.2%)

145 (74.4%)

173 (90.6%)

139 (82.2%)

66 (78.6%)

1,813 (87.2%)

APOE ε4 carriers

481 (63.0%)

218 (65.7%)

96 (51.1%)

90 (51.4%)

98 (53.0%)

39 (42.4%)

51 (61.4%)

1,073 (59.0%)

Mean (SD) baseline scores

        

 ADAS-cog11

21.81 (9.01)

22.97 (9.18)

24.20 (8.75)

27.69 (11.13)

21.37 (6.80)

24.72 (7.72)

21.89 (9.51)

23.02 (9.16)

 ADCS-ADL

62.68 (11.66)

59.34 (13.62)

53.72 (14.17)

49.51 (16.91)

60.45 (11.16)

57.02 (4.80)

59.62 (13.04)

59.16 (13.76)

 MMSE

21.08 (3.67)

21.10 (3.56)

20.37 (3.07)

20.19 (3.15)

20.75 (3.10)

19.49 (3.57)

20.86 (3.49)

20.77 (3.51)

 CDR-SB

5.08 (2.48)

5.41 (2.70)

6.19 (2.74)

7.16 (3.34)

4.95 (2.66)

4.64 (2.53)

5.38 (2.32)

5.41 (2.74)

 NPI

9.21 (10.94)

11.03 (11.73)

12.34 (12.82)

11.24 (11.86)

6.70 (8.69)

7.62 (8.68)

12.13 (10.80)

9.81 (11.13)

  1. Data presented as number (%) or mean (standard deviation). AChEI, acetylcholinesterase inhibitor; AD, Alzheimer’s disease; ADAS-cog11, 11-item Alzheimer’s disease Assessment Scale – cognitive subscale; ADCS-ADL, Alzheimer’s disease Cooperative Study – Activities of Daily Living; APOE, apolipoprotein E; CDR-SB, Clinical Dementia Rating Scale sum of boxes; MMSE, Mini-Mental State Examination; NPI, Neuropsychiatric Inventory; SD, standard deviation.