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Table 2 Correlations between peripheral biomarkers a

From: Peripheral and central effects of γ-secretase inhibition by semagacestat in Alzheimer’s disease

  AUC Plasma Aβ40 Uric acid Albumin EOS GI Skin Skin cancer Infection
AUC 1; 0 −0.36; 0.001 −0.15; 0.007 −0.14; 0.01 0.18; 0.001 0.02; 0.65 −0.02; 0.63 −0.01; 0.81 0.14; 0.001
Plasma Aβ40   1; 0 −0.01; 0.86 0.131; 0.03 −0.19; 0.002 −0.10; 0.03 −0.08; 0.06 −0.08; 0.09 −0.07; 0.11
Uric acid    1; 0 0.08; 0.13 −0.23; 0.001 0.03; 0.60 −0.12; 0.04 −0.08; 0.13 −0.11; 0.04
Albumin     1; 0 −0.22; 0.001 0.05; 0.42 0.02; 0.72 0.02; 0.68 −0.15; 0.006
EOS      1; 0 −0.01; 0.85 0.04; 0.50 0.11; 0.06 0.08; 0.17
GI       1; 0 0.11; 0.001 0.05; 0.16 0.17; 0.001
Skin        1; 0 0.14; 0.001 0.13; 0.001
Skin cancer         1; 0 0.123; 0.001
Infection          1; 0
  1. aAβ40, Amyloid-β peptide 40; AUC, Area under the concentration curve; EOS, Eosinophils; GI, Gastrointestinal. Data are Spearman’s correlation coefficients and P-values (r; P).