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Figure 3 | Alzheimer's Research & Therapy

Figure 3

From: Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research

Figure 3

Altered trajectories. Cognitive function may decline via stepwise decrements upon a declining baseline due to the cumulative effect of multiple acute systemic inflammatory events (SIEs; shown as lightning strikes, with corresponding acute decrements shown on the blue trajectory) but may also progress more rapidly due to the ongoing effects of chronic inflammatory co-morbidities (black, dashed trajectory) such as those discussed herein. The prediction is that underlying pathology such as amyloid beta may not manifest as dementia, or will manifest significantly later (disease without (w/o) acute SIEs, red trajectory), without the influence of these co-morbid factors (data based on [22,23,45]).

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