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Table 3 Area under the receiver operating characteristic curve and optimal value to discriminate subjects with Alzheimer’s disease from those without a

From: Cerebrospinal fluid amyloid-β 42/40 ratio in clinical setting of memory centers: a multicentric study

CSF biomarkers, pg/ml AUC (SE) Optimal value Sensitivity Specificity Youden index
Overall      
  Total tau 0.87 (0.02) 330 0.84 0.81 0.65
  p-tau181 0.90 (0.02) 62 0.79 0.91 0.70
  Aβ42 0.81 (0.02) 752 0.78 0.79 0.57
  Aβ 42/40 0.81 (0.02) 0.055 0.73 0.78 0.51
Center 1      
  Total tau 0.96 (0.01) 300 0.95 0.96 0.91
  pTau-181 0.95 (0.02) 58 0.86 0.91 0.77
  Aβ42 0.81 (0.05) 814 0.84 0.80 0.64
  Aβ 42/40 0.93 (0.03) 0.065 0.89 0.84 0.73
Center 2      
  Total tau 0.91 (0.03) 389 0.86 0.82 0.68
  p-tau181 0.91 (0.03) 64 0.85 0.86 0.71
  Aβ42 0.82 (0.04) 836 0.90 0.71 0.61
  Aβ 42/40 0.87 (0.03) 0.082 0.90 0.67 0.57
Center 3      
  Total tau 0.77 (0.04) 343 0.74 0.77 0.51
  p-tau181 0.84 (0.04) 62 0.72 0.92 0.64
  Aβ42 0.74 (0.05) 737 0.70 0.80 0.50
  Aβ 42/40 0.75 (0.04) 0.050 0.64 0.79 0.43
  1. aAβ, Amyloid-beta; AUC, Area under the receiver operating characteristic curve; CSF, Cerebrospinal fluid; p-tau181, tau phosphorylated at threonine 181; SE, Standard error.