|
CSF biomarkers, pg/ml
|
AUC (SE)
|
Optimal value
|
Sensitivity
|
Specificity
|
Youden index
|
|---|
|
Overall
| | | | | |
| |
Total tau
|
0.87 (0.02)
|
330
|
0.84
|
0.81
|
0.65
|
| |
p-tau181
|
0.90 (0.02)
|
62
|
0.79
|
0.91
|
0.70
|
| |
Aβ42
|
0.81 (0.02)
|
752
|
0.78
|
0.79
|
0.57
|
| |
Aβ 42/40
|
0.81 (0.02)
|
0.055
|
0.73
|
0.78
|
0.51
|
|
Center 1
| | | | | |
| |
Total tau
|
0.96 (0.01)
|
300
|
0.95
|
0.96
|
0.91
|
| |
pTau-181
|
0.95 (0.02)
|
58
|
0.86
|
0.91
|
0.77
|
| |
Aβ42
|
0.81 (0.05)
|
814
|
0.84
|
0.80
|
0.64
|
| |
Aβ 42/40
|
0.93 (0.03)
|
0.065
|
0.89
|
0.84
|
0.73
|
|
Center 2
| | | | | |
| |
Total tau
|
0.91 (0.03)
|
389
|
0.86
|
0.82
|
0.68
|
| |
p-tau181
|
0.91 (0.03)
|
64
|
0.85
|
0.86
|
0.71
|
| |
Aβ42
|
0.82 (0.04)
|
836
|
0.90
|
0.71
|
0.61
|
| |
Aβ 42/40
|
0.87 (0.03)
|
0.082
|
0.90
|
0.67
|
0.57
|
|
Center 3
| | | | | |
| |
Total tau
|
0.77 (0.04)
|
343
|
0.74
|
0.77
|
0.51
|
| |
p-tau181
|
0.84 (0.04)
|
62
|
0.72
|
0.92
|
0.64
|
| |
Aβ42
|
0.74 (0.05)
|
737
|
0.70
|
0.80
|
0.50
|
| |
Aβ 42/40
|
0.75 (0.04)
|
0.050
|
0.64
|
0.79
|
0.43
|
-
aAβ, Amyloid-beta; AUC, Area under the receiver operating characteristic curve; CSF, Cerebrospinal fluid; p-tau181, tau phosphorylated at threonine 181; SE, Standard error.
