|
Characteristics
|
Overall (N = 367)
|
AD (n = 160)
|
Non-AD (n = 207)
|
P
-value
b
|
|---|
|
Age (yr), mean (SD)
|
65.9 (10.7)
|
67.9 (9.7)
|
64.5 (11.2)
|
0.002
|
|
Women, n (%)
|
190 (51.9)
|
97 (60.6)
|
93 (45.2)
|
0.003
|
|
MMSE, mean (SD)
|
22.2 (61.1)
|
20.3 (6.1)
|
23.6 (5.6)
|
<0.001
|
|
CSF biomarkers (pg/ml), mean (SD)
| | | | |
|
Total tau
|
445.4 (334.8)
|
660.5 (349.5)
|
279.2 (202.9)
|
<0.001
|
|
pTau-181
|
62.8 (37.2)
|
89.7 (38.7)
|
42.0 (17.6)
|
<0.001
|
|
Aβ42
|
863.6 (357.3)
|
668.5 (297.3)
|
1,014.5 (325.9)
|
<0.001
|
|
Aβ40
|
15,426.6 (8,630.6)
|
16,383.6 (8,761.3)
|
14,686.9 (8,475.4)
|
0.06
|
|
Aβ 42/40
|
0.068 (0.047)
|
0.047 (0.022)
|
0.084 (0.054)
|
<0.001
|
-
aAβ, Amyloid-beta; AD, Alzheimer’s disease; CSF, Cerebrospinal fluid; MMSE, Mini Mental State Examination; SD, Standard deviation. bBy χ2 test or analysis of variance.
