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Table 1 Characteristics of the study population a

From: Cerebrospinal fluid amyloid-β 42/40 ratio in clinical setting of memory centers: a multicentric study

Characteristics Overall (N = 367) AD (n = 160) Non-AD (n = 207) P -value b
Age (yr), mean (SD) 65.9 (10.7) 67.9 (9.7) 64.5 (11.2) 0.002
Women, n (%) 190 (51.9) 97 (60.6) 93 (45.2) 0.003
MMSE, mean (SD) 22.2 (61.1) 20.3 (6.1) 23.6 (5.6) <0.001
CSF biomarkers (pg/ml), mean (SD)     
Total tau 445.4 (334.8) 660.5 (349.5) 279.2 (202.9) <0.001
pTau-181 62.8 (37.2) 89.7 (38.7) 42.0 (17.6) <0.001
Aβ42 863.6 (357.3) 668.5 (297.3) 1,014.5 (325.9) <0.001
Aβ40 15,426.6 (8,630.6) 16,383.6 (8,761.3) 14,686.9 (8,475.4) 0.06
Aβ 42/40 0.068 (0.047) 0.047 (0.022) 0.084 (0.054) <0.001
  1. aAβ, Amyloid-beta; AD, Alzheimer’s disease; CSF, Cerebrospinal fluid; MMSE, Mini Mental State Examination; SD, Standard deviation. bBy χ2 test or analysis of variance.