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Figure 4 | Alzheimer's Research & Therapy

Figure 4

From: Dementia trials and dementia tribulations: methodological and analytical challenges in dementia research

Figure 4

Modelling cognitive trajectory. (a) Comparing time to dementia and age to describe cognitive trajectories. Mini-Mental State Examination (MMSE) trajectories of a random sample of Origins of Variance in the Oldest-Old Twin Study participants plotted as a function of age and dementia diagnosis. As an illustration of how heterogeneity of trajectories is reduced when scores are modelled using a process-based approach, MMSE scores of a random sample of participants plotted as a function of age and time to dementia diagnosis are depicted [57]. (b) Graphical illustration of a change point model. A schematic representation of the typical change point model trajectory as assumed in the broken stick model [58].

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