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Figure 2 | Alzheimer's Research & Therapy

Figure 2

From: Dementia trials and dementia tribulations: methodological and analytical challenges in dementia research

Figure 2

Methods of assigning dementia diagnosis for clinical research. Differing methods of assigning the dementia outcome are described in terms of the time and effort required to make the diagnosis (x-axis) and the external validity of that diagnosis (y-axis). The positions are illustrative only and designed to show the 'trade off' between effort and validity. In assigning validity we assume that expert clinical assessment is the reference standard; hence, neuropathological assessment requires substantial time/effort but validity is relatively low.

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