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Figure 1 | Alzheimer's Research & Therapy

Figure 1

From: Dementia trials and dementia tribulations: methodological and analytical challenges in dementia research

Figure 1

The theory and reality of contemporary dementia research paradigms. (a) An 'ideal' model, wherein older adults with early biomarker-detected changes of dementia can be selected and this cohort then progresses through a stage of 'cognitive impairment non-dementia' (CIND) with eventual overt dementia of a particular pathological subtype. (b) A more complex situation that is closer to the 'real world' of dementia research, wherein predictive accuracy of biomarkers is not 100% sensitive or specific, CIND to dementia conversion is neither predictable nor inevitable and the final syndrome of dementia is often a mix of underlying pathologies. CSF, cerebrospinal fluid; MCI, mild cognitive impairment.

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