Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer’s disease: a voxel-based lesion mapping study

Table 5 Correlations between gray matter volume and Trail Making Test A performance in APOE ε4 carriers and non-carriers

Location	MNI coordinates			z-value	Cluster-level FWE-corrected P -value
	x	y	z
	TMT A
	Carriers
Right inferior frontal gyrus	38	22	16	4.28	0.01
Right precuneus	14	−51	25	3.48	0.01
Right supramarginal gyrus	57	−34	33	4.47	0.001
Left supramarginal gyrus	−30	−46	37	4.37	0.01
Right superior temporal gyrus	46	−27	15	4.15	0.001
Right middle temporal gyrus	51	−61	−9	3.98	0.01
Left middle temporal gyrus	58	−19	−8	3.47	0.01
Right inferior temporal gyrus	40	−45	−27	4.54	0.001
Left inferior temporal gyrus	−34	−54	−9	4.02	0.01
Right fusiform gyrus	32	−61	−5	4.13	0.001
Left fusiform gyrus	−32	−52	−9	4.07	0.01
	Non-carriers
Right precuneus	8	−48	43	4.31	0.01
Right supramarginal gyrus	39	−34	37	3.36	0.01
Left supramarginal gyrus	−44	−31	24	3.53	0.05
Right angular gyrus	54	−54	33	3.89	0.05
Left angular gyrus	−42	−42	42	3.65	0.05
Right superior parietal lobule	39	−58	54	3.42	0.05
Right inferior parietal lobule	44	−52	48	3.39	0.05
Right middle temporal gyrus	54	−55	24	3.45	0.05
Left middle temporal gyrus	−44	−45	12	3.98	0.05
	Delayed verbal recall
	Carriers
Right hippocampus	36	−30	−8	2.65	0.08^b
Left hippocampus	−33	−34	−8	3.49	0.01^b
	Non-carriers
	–	–	–	–	–

^aMNI, Montreal Neurological Institute. ^bVoxel-level family-wise error (FWE)–corrected threshold P-values within region of interest.

ISSN: 1758-9193