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Table 1 Characteristics of patients with probable Alzheimer’s disease according to new diagnostic guidelines a

From: Apolipoprotein E-dependent load of white matter hyperintensities in Alzheimer’s disease: a voxel-based lesion mapping study

  APOE ε4 carriers (n = 120) APOE ε4 non-carriers (n = 63) Group comparison P -values b
Total number of patients N = 183  
Age (yr) 70.4 ± 6.4 70.4 ± 8.7 0.97
Age at onset (yr) 67.6 ± 7.2 66.8 ± 12.2 0.96
Duration of disease (mo) 31.3 ± 24.7 30.5 ± 25.4 0.84
Males/females, n (ratio) 57/63 (1:1.1) 28/35 (1:1.3) 0.70
Education (yr) 9.1 ± 1.8 9.4 ± 2.2 0.30
Systolic blood pressure (mmHg) 139.3 ± 17.0c 141.1 ± 16.9d 0.54
Systolic blood pressure ≥140 mmHg (yes/no) 57/42 (1.4 : 1) 32/23 (1.4 : 1) 0.95
Diastolic blood pressure (mmHg) 81.6 ± 8.7c 83.8 ± 7.9d 0.14
Diastolic blood pressure ≥90 mmHg (yes/no) 33/66 (1:2) 20/35 (1:1.8) 0.78
Antihypertensive medication (yes/no) 31/87 (1 : 2.8)e 20/39 (1 : 2)f 0.18
Coronary heart disease (yes/no) 7/111 (1 : 15.9)e 5/56 (1 : 9.3)g 0.57
Diabetes (yes/no) 16/102 (1 : 6.4)e 6/53 (1 : 8.8)f 0.45
Hypercholesterolemia (yes/no) 15/100 (1 : 6.7)h 7/47 (1 : 6.7)i 0.99
BMI 24.5 ± 3.9j 24.2 ± 4.9i 0.85
CDR SOB 4.3 ± 1.4 4.3 ± 1.6 0.92
MMSE (score) 23.8 ± 3.2k 24.5 ± 2.9 0.51
Delayed verbal recall (score) 2.1 ± 2.0j 2.8 ± 2.2 0.02
Verbal learning 12.1 ± 4.3j 12.4 ± 4.4 0.87
Trail Making Test A (s) 96.6 ± 57.0l 96.1 ± 52.3 0.60
Constructive -apraxia 9.0 ± 2.3k 9.0 ± 1.8 0.59
Boston Naming Test 12.6 ± 2.4k 12.8 ± 2.4 0.80
  1. a APOE, Apolipoprotein E; BMI, Body mass index; CDR SOB, Clinical Dementia Rating Sum of Boxes; MMSE, Mini Mental State Examination. Data are presented as mean ± SD or ratio. b P-values are based on Student’s t-test. Available data: cn = 99, dn = 55, en = 118, fn = 59, gn = 61, hn = 115, in = 54, jn = 99, kn = 119, ln = 116.