APP/PS1 mice have frequent epileptiform discharges. (A) Spontaneous generalized convulsive seizure, (B) spike-wave discharge (SWD) (arrows) and (C) single spike in a 10-month-old APP/PS1 mouse (arrows). The arrowheads indicate normal electroencephalogram background following single spike. (D) Quantification of SWDs in APP/PS1 mice compared with their wild-type (WT) littermates. (E) Quantification of single spikes does not show a difference between APP/PS1 mice and WT littermates (n = 8 for WT, 19 for APP/PS1). *P < 0.05 by Student’s t-test. WT, five females and three males; APP/PS1 mice with SWDs, four males and five females; APP/PS1 mice without SWDs, six females and four males. Calibration: SWD = 200 μV/0.5 s; spike = 200 μV/1 s.