Assessment | Parameter | PBO | MEM | PBO-DON | MEM-DON |
---|---|---|---|---|---|
number = 281 | number = 289 | number = 418 | number = 429 | ||
SIB | AUC0-24 a | −51.4 ± 10.9 | 4.9 ± 10.5 | 27.5 ± 8.6 | 67.4 ± 8.3 |
│Xb - PBO│c | 0 | 56.3* | 78.9*** | 118.8*** | |
│Xb - PBO│/│PBO│, % | - | 109.6 | 153.5 | 231.1 | |
ADCS-ADL19 | AUC0-24 a | −32.7 ± 6.4 | −12.2 ± 6.2 | −9.5 ± 5.0 | 1.4 ± 4.9 |
│Xb - PBO│c | 0 | 20.5 | 23.3* | 34.2*** | |
│Xb - PBO│/│PBO│, % | - | 62.6 | 71.1 | 104.4 | |
NPId | AUC0-24 a | 22.4 ± 12.2 | −7.3 ± 11.8 | −27.2 ± 9.7 | −74.3 ± 9.4 |
│Xb - PBO│c | 0 | 29.8 | 49.6** | 96.8*** | |
│Xb - PBO│/│PBO│, % | - | 132.5 | 221.0 | 431.2 | |
CIBIC-Plus | AUC0-24 a | 6.0 ± 1.1 | 2.0 ± 1.0 | 1.4 ± 0.9 | −2.1 ± 0.8 |
│Xb - PBO│c | 0 | 4.0 | 4.6* | 8.1*** | |
│Xb - PBO│/│PBO│, % | - | 65.9 | 76.2 | 135.6 | |
4D-CI | AUC0-24 a | −175.4 ± 63.7 | 152.1 ± 61.5 | 344.7 ± 50.4 | 630.0 ± 49.0 |
│Xb - PBO│c | 0 | 327.4** | 520.0*** | 805.4*** | |
│Xb - PBO│/│PBO│, % | - | 186.7 | 296.6 | 459.3 |