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Table 2 Baseline characteristics of pooled populations

From: Cumulative, additive benefits of memantine-donepezil combination over component monotherapies in moderate to severe Alzheimer’s dementia: a pooled area under the curve analysis

Parameter Statistic/Category PBO MEM PBO-DON MEM-DON
Age, years number 281 289 418 429
Range 51 to 97 50 to 95 50 to 97 50 to 95
Mean ± SD 77.3 ± 7.8 77.2 ± 8.3 76.1 ± 8.3 75.8 ± 8.2
P-value 0.0378b
Sexa Men 91 (32) 79 (27) 130 (31) 144 (34)
Women 190 (68) 210 (73) 288 (69) 285 (66)
P-value 0.3482c
Racea Non-white 40 (14) 47 (16) 24 (6) 24 (6)
White 241 (86) 242 (84) 394 (94) 405 (94)
P-value <0.0001b
Weight, kg Number 281 285 418 429
Range 39 to 106 31 to 110 39 to 128 36 to 113
Mean ± SD 65.9 ± 13.3 64.4 ± 13.0 65.4 ± 13.9 67.9 ± 14.0
P-value 0.0049b
MMSE score Number 281 289 418 429
Range 1 to 16 2 to 15 3 to 15 3 to 16
Mean ± SD 9.3 ± 3.5 9.0 ± 3.4 10.6 ± 2.9 10.6 ± 3.0
P-value <0.0001b
  1. aData are presented as number (%); banalysis of variance (ANOVA); cChi-squared test.
  2. DON, donepezil; MEM, memantine; MMSE, Mini Mental State Exam; PBO, placebo; SD, standard deviation.