Figure 5

4D-CI Composite Index: Snapshot and AUC analysis ^a . ^aIn panels A and B, statistical comparisons are made between groups; in C and D, statistical comparisons are made with respect to no change from baseline (zero change from baseline) and zero AUC, respectively. ^bAUC values corrected for interval duration (four or six weeks). **P <0.01 ***P <0.001. 4D-CI, four-dimensional composite index; AUC, area under the curve; LS, least squares; MEM, memantine; MEM-DON, memantine added to background donepezil treatment; PBO, placebo; PBO-DON, placebo added to background donepezil treatment; SE, standard error of the mean.