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Table 4 Association between neuropsychological symptoms and pathology groups (when compared to associations with a no pathology group, unadjusted)

From: Alpha-synucleinopathy and neuropsychological symptoms in a population-based cohort of the elderly

Neuropsychological measure

High NFT only

AS + high NFT

AS + low NFT

 

n

N

OR 95% CI

P

n

N

OR 95% CI

P

n

N

OR 95% CI

MMSE score <21

32

43

3.53 (1.30 - 10.01)

<0.01

23

32

2.21 (0.81 - 6.27)

>0.2

25

52

0.96 (0.41 - 2.26)

Dementia

30

43

3.68 (1.37 - 10.08)

<0.01

24

32

4.63 (1.52 - 15.07)

<0.01

17

52

0.88 (0.35 - 2.22)

Low CAMCOG Attention

25

43

1.29 (0.41 - 4.27)

>0.2

15

32

0.69 (0.21 - 2.32)

>0.2

23

52

0.56 (0.20 - 1.54)

Low CAMCOG Languagea

27

43

2.05 (0.56 - 8.46)

>0.2

21

32

1.99 (0.49 - 9.68)

>0.2

26

52

0.7 (0.24 - 2.02)

Low CAMCOG Abstract thinking

18

43

1.93 (0.68 - 5.51)

>0.2

13

32

1.62 (0.53 - 5.02)

>0.2

20

52

1.5 (0.57 - 4.00)

Low CAMCOG Perception

27

43

2.33 (0.70 - 8.47)

>0.2

16

32

0.83 (0.27 - 2.63)

>0.2

31

52

2.01 (0.66 - 6.39)

Low CAMCOG Totalb

29

43

3.67 (0.83 - 22.20)

>0.2

19

32

1.44 (0.38 - 6.13)

>0.2

26

52

0.82 (0.28 - 2.43)

 

DLB Consensus + high NFT

Amygdala-predominant + high NFT

other AS pattern + high NFT

MMSE score <21

10

13

3.21 (0.70 - 19.89)

>0.2

7

9

2.24 (0.44 - 14.76)

>0.2

6

10

1.44 (0.30 - 7.77)

Dementia

10

13

4.5 (0.96 - 28.04)

0.06

7

9

4.72 (0.77 - 49.99)

0.07

7

10

4.72 (0.77 - 49.99)

Low CAMCOG Attention

7

13

1.45 (0.23 - 16.15)

>0.2

4

9

0.41 (0.07 - 2.66)

>0.2

4

10

0.55 (0.08 - 4.40)

Low CAMCOG Languagea

9

13

3.41 (0.38 -163.00)

>0.2

7

9

2.66 (0.28-130.36)

>0.2

5

10

0.95 (0.13 - 11.36)

Low CAMCOG Abstract thinking

4

13

1.2 (0.20 - 6.54)

>0.2

5

9

1.88 (0.34 - 10.87)

>0.2

4

10

2 (0.29 - 15.30)

Low CAMCOG Perception

8

13

2.07 (0.34 - 22.35)

>0.2

5

9

0.65 (0.12 - 3.85)

>0.2

3

10

0.39 (0.05 - 2.71)

Low CAMCOG Totalb

8

13

3.03 (0.33 -146.68)

>0.2

5

9

0.63 (0.10 - 4.81)

>0.2

6

10

2.28 (0.23-114.05)

 

DLB Consensus + low NFT

Amygdala-predominant + low NFT

other AS pattern + low NFT

MMSE score <21

13

20

1.39 (0.45 - 4.38)

>0.2

1

9

0.12 (0.00 - 1.04 )

>0.2

11

23

1.32 (0.40 - 4.46)

Dementia

12

20

3.24 (0.87 - 13.47)

0.09

0

9

0 (0.00 - 0.62)

>0.2

5

23

0.56 (0.13 - 2.09)

Low CAMCOG Attention

10

20

0.83 (0.20 - 3.78)

>0.2

1

9

0.07 (0.00 - 0.70)

>0.2

12

23

0.83 (0.22 - 3.35)

Low CAMCOG Languagea

9

20

0.57 (0.14 - 2.45)

>0.2

5

9

0.95 (0.13 - 11.36)

>0.2

12

23

0.76 (0.20 - 3.11)

Low CAMCOG Abstract thinking

6

20

1 (0.24 - 3.91)

>0.2

2

9

0.6 (0.05 - 4.29)

>0.2

12

23

3 (0.82 -11.68)

Low CAMCOG Perception

9

20

0.93 (0.23 - 4.26)

>0.2

6

9

3.11 (0.32-153.14)

>0.2

16

23

4.15 (0.77 - 41.44)

Low CAMCOG Totalb

7

20

0.44 (0.10 - 2.01)

>0.2

6

9

2.28 (0.23-114.05)

>0.2

13

23

0.99 (0.25 - 4.38)

  1. aComprehension and Expression; bover seven CAMCOG domains. AS, alpha-synucleinopathy; CAMCOG, Cambridge Cognitive Examination; CI, confidence interval; DLB, dementia with Lewy bodies; MMSE, Mini Mental State Examination; NFT, neurofibrillary tangles; OR, odds ratio.