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Table 5 Demographic data and biomarker concentrations for all cerebrospinal fluid samples

From: A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

  Diagnosis n Sex (male/female) Age (years) MMSE score Aβ1–42 (pg/ml) Total tau (pg/ml) Phosphorylated tau (pg/ml) oAβ (pg/ml)
Cohort 1 AD 10 3/7 72 N/A 442.6 ± 27.4 1101 ± 112.5 119.1 ± 8.2 0.9 ± 0.2
(54 to 84)   (316, 568) (609, 1,850) (81,172) (0.4, 2.4)
Normal 10 5/5 72 N/A 829.8 ± 57.3 239.5 ± 15.8 35.9 ± 2.1 0.7 ± 0.1
(62 to 81)   (607, 1,100) (129, 315) (26, 45) (0.4, 1.4)
Cohort 2 AD 10 6/4 72 18 184.4 ± 11.2 154.9 ± 22.5 34.4 ± 3.2 0.2 ± 0.0
(50 to 86) (11 to 20) (147, 236) (70, 247) (22, 47) (0.1, 0.3)
MCI 10 6/4 81 25 250.0 ± 25.6 142.3 ± 15.6 31.3 ± 4.3 0.3 ± 0.1
(76 to 89) (23 to 28) (165, 383) (80, 207) (17, 59) (0.1, 0.8)
Normal 10 4/6 79 28 251.1 ± 34.1 58.8 ± 6.4 16.7 ± 1.8 0.2 ± 0.0
(75 to 82) (27 to 29) (126, 399) (36, 84) (10, 25) (0, 0.4)
Cohort 3 MCI 23 16/7 75 28 386.6 ± 30.0 152.4 ± 29.4 46.1 ± 5.1 0.9 ± 0.1
(60 to 85) (25 to 30) (201, 599) (39, 530) (20, 90) (0.3, 2.7)
Normal 17 7/10 70 29 475.4 ± 23.1 95.5 ± 20.0 30.7 ± 5.3 0.6 ± 0.1
(55 to 86) (27 to 30) (352, 590) (26, 285) (11, 77) (0.3, 1.3)
  1. Data presented as mean ± standard error of the mean (range). AD, Alzheimer’s disease; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; oAβ, amyloid-beta oligomers.