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Table 5 Demographic data and biomarker concentrations for all cerebrospinal fluid samples

From: A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

 

Diagnosis

n

Sex (male/female)

Age (years)

MMSE score

Aβ1–42 (pg/ml)

Total tau (pg/ml)

Phosphorylated tau (pg/ml)

oAβ (pg/ml)

Cohort 1

AD

10

3/7

72

N/A

442.6 ± 27.4

1101 ± 112.5

119.1 ± 8.2

0.9 ± 0.2

(54 to 84)

 

(316, 568)

(609, 1,850)

(81,172)

(0.4, 2.4)

Normal

10

5/5

72

N/A

829.8 ± 57.3

239.5 ± 15.8

35.9 ± 2.1

0.7 ± 0.1

(62 to 81)

 

(607, 1,100)

(129, 315)

(26, 45)

(0.4, 1.4)

Cohort 2

AD

10

6/4

72

18

184.4 ± 11.2

154.9 ± 22.5

34.4 ± 3.2

0.2 ± 0.0

(50 to 86)

(11 to 20)

(147, 236)

(70, 247)

(22, 47)

(0.1, 0.3)

MCI

10

6/4

81

25

250.0 ± 25.6

142.3 ± 15.6

31.3 ± 4.3

0.3 ± 0.1

(76 to 89)

(23 to 28)

(165, 383)

(80, 207)

(17, 59)

(0.1, 0.8)

Normal

10

4/6

79

28

251.1 ± 34.1

58.8 ± 6.4

16.7 ± 1.8

0.2 ± 0.0

(75 to 82)

(27 to 29)

(126, 399)

(36, 84)

(10, 25)

(0, 0.4)

Cohort 3

MCI

23

16/7

75

28

386.6 ± 30.0

152.4 ± 29.4

46.1 ± 5.1

0.9 ± 0.1

(60 to 85)

(25 to 30)

(201, 599)

(39, 530)

(20, 90)

(0.3, 2.7)

Normal

17

7/10

70

29

475.4 ± 23.1

95.5 ± 20.0

30.7 ± 5.3

0.6 ± 0.1

(55 to 86)

(27 to 30)

(352, 590)

(26, 285)

(11, 77)

(0.3, 1.3)

  1. Data presented as mean ± standard error of the mean (range). AD, Alzheimer’s disease; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; oAβ, amyloid-beta oligomers.