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Table 3 Comparison of sensitivities (LLoQ) of the 1C22/3D6B amyloid-beta oligomer assay using the MSD versus Erenna platforms

From: A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

ELISA platform ADDLs (pg/ml) (S26C) 2 (pg/ml) Dityrosine (pg/ml)
Erenna 0.15 40.6 ± 9.3 375 ± 84.6
MSD 18.7 187 ± 54 601 ± 107
  1. LLoQ is the lowest back-interpolated standard that provides a signal two-fold greater than background with a coefficient of variance <20%. ADDL, amyloid-beta-derived diffusible ligand; ELISA, enzyme-linked immunosorbent assay; LLoQ, lower limit of reliable quantification. Erenna platform (Singulex, Alameda, CA, USA) and MSD Multi-Array (Meso Scale Discovery, Gaithersburg, MD, USA).