The relationship of weight change trajectory with medial temporal lobe atrophy in patients with mild Alzheimer’s disease: results from a cohort study

Table 8 Patient characteristics at baseline: right MTA score of 0 or 1 versus 2, 3 or 4

	MTA score 0 or 1	MTA score 2, 3, 4	P
Age (year): n, median [25^th -75^th percentile]	17, 73.0 [72.0 - 79.0]	197, 79.0 [76.0 - 82.0]	0.003^b**
Women, n (%)	9 (52.9)	123 (62.4)	ns^c
Social status
alone, n (%)	8 (47.1)	85 (44.7)	ns^c
with partner, n (%)	9 (52.9)	99 (52.1)
other*, n (%)	0 (0. 0)	6 (3.2)
CIRS (score): n, median [25^th -75^th percentile]	17, 5.0 [4.0 - 6.5]	197, 6.0 [4.0 - 8.0]	ns^b
Polypharmacy, n (%)	7 (41.2)	106 (54.1)	ns^c
Use of informal care, n (%)	11 (64.7)	171 (87.2)	0.022^d**
Use of professional care, n (%)	5 (29.4)	94 (48.5)	ns^c
MMSE (score): n, median [25^th -75^th percentile]	17, 25.0 [22.0 - 27.5]	195, 23.0 [20.0 - 25.0]	0.026^b**
Clock-drawing test (score): n, median [25^th -75^th percentile]	16, 3.0 [1.0 - 4.0]	177, 3.0 [2.0 - 5.0]	ns^b
Presence of BPS, n (%)	3 (17.7)	48 (25.0)	ns^d
Weight (kg): n, mean ± SD	17, 70 ± 11	197, 74 ± 12	ns^a
BMI (weight/(height)²): n, median [25^th -75^th percentile]	15, 25.6 [21.5 - 27.0]	188, 25.9 [23.5 - 28.9]	ns^b
Use of ONS, n (%)	0 (0.0)	1 (0.6)	ns^d
Appetite
good, n (%)	16 (100)	154 (92.2)	ns^d
poor, n (%)	0 (0.0)	13 (7.8)	ns^d
Self reported weight loss, n (%)	0 (0.0)	28 (15.8)	ns^d

*Other, that is: with son or daughter, brother or sister; **significant, that is P <0.05. ^aIndependent sample t test; ^bMann-Whitney U test; ^cPearson chi-square test; ^dFisher’s exact.
MTA, medial temporal lobe atrophy; P, probability; n, number of patients; ns, not significant; CIRS, cumulative illness rating scale; MMSE, mini mental state examination; BPS, behavioral and psychological symptoms; SD, standard deviation; BMI, body mass index; ONS, oral nutritional supplement.

ISSN: 1758-9193