Predicting amyloid status in corticobasal syndrome using modified clinical criteria, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography

Table 1 Modified corticobasal syndrome criteria

I. CBS: core criteria
Inclusion criteria (1 plus 2)
	1. Progressive course
	2. At least three of the following:
		a. Parkinsonism (bradykinesia or rigidity)
		b. Dystonia
		c. Myoclonus
		d. Impairment in voluntary limb control (alien limb)
		e. Cortical sensory deficit (symmetric/asymmetric)
Exclusion criteria (all must be negative)
		a. Visual hallucinations
		b. REM sleep behavior disorder
		c. Cerebellar ataxia
		d. Prominent autonomic dysfunction
		e. Fluctuations in alertness
		f. Prominent rest tremor
II. CBS- frontal variant:
Inclusion criteria (meets core plus one of the following must be positive)
	1. Agrammatism, non-fluent speech or motor speech deficits
	2. Apathy, disinhibition or loss of empathy
	3. Apraxia primarily affecting lower extremities
	4. Prominent executive dysfunction greater than memory or visuospatial impairment
III. CBS- temporoparietal variant:
Inclusion criteria (meets core plus one of the following must be positive)
	1. Logopenic aphasia [16]
	2. Elements of Gerstmann or Balint syndrome
	3. Episodic memory or visuospatial impairment greater than executive dysfunction

ISSN: 1758-9193