The monoaminergic footprint of depression and psychosis in dementia with Lewy bodies compared to Alzheimer’s disease

Vermeiren, Yannick; Van Dam, Debby; Aerts, Tony; Engelborghs, Sebastiaan; Martin, Jean-Jacques; De Deyn, Peter P

doi:10.1186/s13195-014-0090-1

Alzheimer's Research & Therapy

Table 4 Significant brain monoaminergic correlates of NPS in DLB and AD

From: The monoaminergic footprint of depression and psychosis in dementia with Lewy bodies compared to Alzheimer’s disease

Study group	Brain region	MA and MT or ratio	NPS feature	Spearman’s Rank Order correlation statistics
DLB patients
Number = 10
	BA10	DA (ng/g tissue)	CMAI cluster 3	R = +0.841, P = 0.002, number = 10
	BA10	DA (ng/g tissue)	verbal agitation	R = +0.841, P = 0.002, number = 10
	hippocampus	DA (ng/g tissue)	Behave-AD cluster AB	R = +0.928, P = 0.0001, number = 10
	hippocampus	DA (ng/g tissue)	psychosis	R = +0.928, P = 0.0001, number = 10
		DA (ng/g tissue)	Behave-AD total score	R = +0.825, P = 0.003, number = 10
	thalamus	DA (ng/g tissue)	CSDD total scores	R = +0.839, P = 0.002, number = 10
	thalamus	DA (ng/g tissue)	depression	R = +0.839, P = 0.002, number = 10
		HVA/DA ratio	CSDD total scores	R = −0.851, P = 0.002, number = 10
		HVA/DA ratio	depression	R = −0.851, P = 0.002, number = 10
	BA22	DA (ng/g tissue)	CMAI total score	R = +0.827, P = 0.003, number = 10
	BA22	DA (ng/g tissue)	agitation	R = +0.827, P = 0.003, number = 10
	cerebellum	DOPAC/DA ratio	Behave-AD cluster F	R = −0.846, P = 0.002, number = 10
	cerebellum	DOPAC/DA ratio	affective disturbances	R = −0.846, P = 0.002, number = 10
AD patients
Number = 20
	amygdala	DA (ng/g tissue)	Behave-AD cluster AB	R = −0.728, P = 0.0009, number = 17
	amygdala	DA (ng/g tissue)	psychosis	R = −0.728, P = 0.0009, number = 17
		HVA/DA ratio	Behave-AD cluster AB	R = +0.766, P = 0.0003, number = 17
		HVA/DA ratio	psychosis	R = +0.766, P = 0.0003, number = 17
		HVA/DA ratio	CMAI cluster 3	R = +0.786, P = 0.0002, number = 17
		HVA/DA ratio	verbal agitation	R = +0.786, P = 0.0002, number = 17
		HVA/DA ratio	CMAI total score	R = +0.671, P = 0.003, number = 17
		HVA/DA ratio	agitation	R = +0.671, P = 0.003, number = 17
	hippocampus	HVA/5-HIAA ratio	Behave-AD cluster C	R = +0.659, P = 0.002, number = 19
	hippocampus	HVA/5-HIAA ratio	activity disturbances	R = +0.659, P = 0.002, number = 19
	BA17	HVA/DA ratio	Behave-AD cluster F	R = −0.670, P = 0.002, number = 19
	BA17	HVA/DA ratio	affective disturbances	R = −0.670, P = 0.002, number = 19
		DA (ng/g tissue)	CSDD total scores	R = +0.662, P = 0.002, number = 19
		DA (ng/g tissue)	depression	R = +0.662, P = 0.002, number = 19
	LC	MHPG/NA ratio	Behave-AD cluster D	R = +0.727, P = 0.001, number = 16
	LC	MHPG/NA ratio	agitation and aggression	R = +0.727, P = 0.001, number = 16

Significant correlations between NPS and neurochemical data in postmortem brain tissue samples of DLB and AD patients as indicated by Spearman’s Rank Order correlation statistics (correlation coefficient (R), P value and sample size (n)). Only correlations remaining statistically significant following Bonferroni correction are displayed above (P <0.0033). The four most significant correlations (P <0.001) are shown in bold. 5-HIAA, 5-hydroxy-3-indoleacetic acid; AD, Alzheimer’s disease; BA, Brodmann area; Behave-AD, Behavioral Pathology in Alzheimer’s Disease Rating Scale; CMAI, Cohen-Mansfield Agitation Inventory; CSDD, Cornell Scale for Depression in Dementia; DA, dopamine; DLB, dementia with Lewy bodies; DOPAC, 3,4-dihydroxyphenylacetic acid; HVA, homovanillic acid; LC, locus coeruleus; MA and MT, monoamines and metabolites; MFS, Middelheim Frontality Score; MHPG, 3-methoxy-4-hydroxyphenylglycol; NA, noradrenaline; NPS, neuropsychiatric symptoms.

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ISSN: 1758-9193

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