MHPG concentrations across different brain regions in DLB + D compared to AD + D, AD-D and CONTR. Data are presented as mean with SD. Nonparametric Mann–Whitney U statistics were performed. MHPG levels of seven out of eleven postmortem brain regions were significantly decreased in DLB + D compared to AD + D and/or AD-D patients (P values vary from <0.05 to <0.001). In BA17, MHPG concentrations of DLB + D patients were significantly higher. AD + D/-D, depressed/nondepressed Alzheimer’s disease patients; BA, Brodmann area; CONTR, control subjects; DLB + D, depressed dementia with Lewy bodies patients; LC, locus coeruleus; MHPG, 3-methoxy-4-hydroxyphenylglycol.