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Table 2 Small molecule BACE1 inhibitors in clinical trials

From: BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

Company Drug Phase
AstraZeneca/Lilly AZD3293 Phase 2/3
CoMentis CTS-21166 Phase 1
Eisai/Biogen Idec E2609 Phase 2
High Point HPP854 Phase 1
Janssen/Shionogi - - - - - - Phase 1
Lilly LY2886721 Phase 2*
Merck MK-8931 Phase 2/3
Novartis - - - - - - Phase 1
Pfizer PF-05297909 Phase 1
Roche RG7129 Phase 1**
Takeda TAK-070 Phase 1
Vitae/Boehringer Ingelheim VTP-37948 Phase 1
  1. *Terminated due to abnormal liver biochemistry.
  2. **Removed from pipeline.