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Figure 3 | Alzheimer's Research & Therapy

Figure 3

From: BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

Figure 3

Neuronal substrates of BACE1. BACE1 substrates identified in primary cultured neurons are listed from those that are predominantly cleaved by BACE1 (BACE1 cleavage HIGH; top) to those that are processed by BACE1 at a low level (LOW; bottom). These substrates also are cleaved by other proteases in the ADAM family, but the ADAM cleavage preference is opposite to that of BACE1. (Adapted from Table I, Ref. [56]).

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