Figure 2

Summary of the concept of mixed pathologies. The holistic approach suggests that the number of combinations of different neuropathological substrates might be very high. Different combinations are covered by the umbrella term mixed pathologies. Aβ, amyloid beta; AD, Alzheimer’s disease; ALB, amygdala predominant Lewy body pathology; AGD, argyrophilic grain disease; CAA, cerebral amyloid angiopathy; CBD, corticobasal degeneration; MSA, multiple system atrophy; PSP, progressive supranuclear palsy; TDP-43, TAR DNA-binding protein 43; TPD, tangle-predominant dementia.