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Table 2 Significant clusters resulting from voxelwise t -tests comparing CVRi and CBF between young-old and very-old groups

From: Elevated cerebrovascular resistance index is associated with cognitive dysfunction in the very-old

Region Volume (mm 3 ) Maximum intensity (x, y, z) Maximum intensity t
CVRi    
(1) L/R Cuneus/lingual gyrus 3136 6 L, 69P, −8I 2.46
(2) R Paraphippocampal gyrus/superior temporal gyrus/caudate 1536 −42R, 41P, −20I 2.08
CBF    
(1) L Caudate/lentiform nucleus 1600 14 L, 1P, 8S −2.38
(2) L/R Posterior cingulate, L/R cuneus, L precuneus 1280 −6R, 61P, 8S −2.57
(3) L/R Medial frontal gyrus 1280 2 L, −43A, 24S −3.04
PP/CBF    
(1) L/R Lingual gyrus/cuneus 3136 14 L 69P -12I 2.05
(2) R Insula/inferior frontal gyrus 2816 −42R 5P -8I 4.66
(3) R Middle frontal gyrus/R superior frontal gyrus 2112 −34R -23A 32S 2.94
(4) R Inferior parietal lobule/supramarginal gyrus 1920 −58R 29P 32S 2.60
(5) R Superior frontal gyrus/R middle frontal gyrus 1664 −26R -55A 0 2.37
(6) R Middle temporal gyrus 1664 −42R 49P 8S 2.42
(7) R Thalamus/caudate/cingulate gyrus 1472 −14R 5P 12S 2.00
(8) R Fusiform gyrus/paraphippcampal gyrus/caudate 1344 −42R 41P -20S 2.41
(9) L Middle frontal gyrus 1280 22 L -31A 36S 2.28
  1. Clusters shown survived our cluster threshold alpha-protection procedure (P < .05, volume >1,280 mm3). A, anterior; CBF, cerebral blood flow: CVRi, index of cerebrovascular resistance; I, inferior; L, left; P, posterior; R, right; PP, pulse pressure; S, superior.