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Table 2 Significant clusters resulting from voxelwise t -tests comparing CVRi and CBF between young-old and very-old groups

From: Elevated cerebrovascular resistance index is associated with cognitive dysfunction in the very-old

Region

Volume (mm 3 )

Maximum intensity (x, y, z)

Maximum intensity t

CVRi

   

(1) L/R Cuneus/lingual gyrus

3136

6 L, 69P, −8I

2.46

(2) R Paraphippocampal gyrus/superior temporal gyrus/caudate

1536

−42R, 41P, −20I

2.08

CBF

   

(1) L Caudate/lentiform nucleus

1600

14 L, 1P, 8S

−2.38

(2) L/R Posterior cingulate, L/R cuneus, L precuneus

1280

−6R, 61P, 8S

−2.57

(3) L/R Medial frontal gyrus

1280

2 L, −43A, 24S

−3.04

PP/CBF

   

(1) L/R Lingual gyrus/cuneus

3136

14 L 69P -12I

2.05

(2) R Insula/inferior frontal gyrus

2816

−42R 5P -8I

4.66

(3) R Middle frontal gyrus/R superior frontal gyrus

2112

−34R -23A 32S

2.94

(4) R Inferior parietal lobule/supramarginal gyrus

1920

−58R 29P 32S

2.60

(5) R Superior frontal gyrus/R middle frontal gyrus

1664

−26R -55A 0

2.37

(6) R Middle temporal gyrus

1664

−42R 49P 8S

2.42

(7) R Thalamus/caudate/cingulate gyrus

1472

−14R 5P 12S

2.00

(8) R Fusiform gyrus/paraphippcampal gyrus/caudate

1344

−42R 41P -20S

2.41

(9) L Middle frontal gyrus

1280

22 L -31A 36S

2.28

  1. Clusters shown survived our cluster threshold alpha-protection procedure (P < .05, volume >1,280 mm3). A, anterior; CBF, cerebral blood flow: CVRi, index of cerebrovascular resistance; I, inferior; L, left; P, posterior; R, right; PP, pulse pressure; S, superior.