Fitting the epidemiology and neuropathology of the early stages of Alzheimer’s disease to prevent dementia

Table 4 Prevalence by age group and type of classification (clinical and pathological) in the Spanish population

		Clinical classification ^a			Pathological classification ^b
Age group	Population	Preclinical	Prodromal	Dementia	Thal1	Thal2	Thal3
Number
40 to 44	2,981,900	252,700	800	0	253,500	16,900	9,400
45 to 49	3,530,900	388,400	4,900	0	393,300	47,200	19,800
50 to 54	3,109,400	431,800	9,400	1,100	442,300	93,600	31,600
55 to 59	2,620,100	517,600	19,400	3,200	540,200	172,400	49,900
60 to 64	2,438,200	739,200	43,500	9,200	791,900	336,900	82,400
65 to 69	2,091,000	929,800	79,800	17,800	1,027,400	461,000	120,900
70 to 74	1,705,800	817,900	148,900	31,300	998,100	583,200	178,600
75 to 79	1,653,700	699,100	291,800	58,200	1,049,100	814,400	266,400
80 to 84	1,218,300	329,500	418,600	90,500	838,600	709,500	277,300
85 to 89	659,500	67,200	330,800	90,400	488,400	416,600	195,600
90 to 94	215,100	14,100	97,300	52,200	163,600	136,000	74,700
>95	38,400	2,700	9,100	16,400	28,200	22,800	14,100
Total >40	22,262,300	5,190,000	1,454,300	370,300	7,014,600	3,810,500	1,320,700
Total >60	10,020,000	3,599,500	1,419,800	366,000	5,385,300	3,480,400	1,210,000
Percentage
40 to 44	100.0	8.5	0.0	0.0	8.5	0.6	0.3
45 to 49	100.0	11.0	0.1	0.0	11.1	1.3	0.6
50 to 54	100.0	13.9	0.3	0.0	14.2	3.0	1.0
55 to 59	100.0	19.8	0.7	0.1	20.6	6.6	1.9
60 to 64	100.0	30.3	1.8	0.4	32.5	13.8	3.4
65 to 69	100.0	44.5	3.8	0.9	49.1	22.0	5.8
70 to 74	100.0	47.9	8.7	1.8	58.5	34.2	10.5
75 to 79	100.0	42.3	17.6	3.5	63.4	49.2	16.1
80 to 84	100.0	27.0	34.4	7.4	68.8	58.2	22.8
85 to 89	100.0	10.2	50.2	13.7	74.1	63.2	29.7
90 to 94	100.0	6.6	45.2	24.3	76.1	63.2	34.7
>95	100.0	7.0	23.7	42.7	73.4	59.4	36.7
Total >40	100.0	23.3	6.5	1.7	31.5	17.1	5.9
Total >60	100.0	35.9	14.2	3.7	53.7	34.7	12.1

^aData for clinical stages are not aggregated. ^bData for pathological classification prevalence are aggregated.

ISSN: 1758-9193