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Figure 5 | Alzheimer's Research & Therapy

Figure 5

From: Evaluating the relationship between amyloid-β and α-synuclein phosphorylated at Ser129 in dementia with Lewy bodies and Parkinson’s disease

Figure 5

Soluble Aβ and α-syn levels in controls, PDND, PDD and DLB. Box-and-whisker plots indicate the full range, interquartile range and median value in each group. Soluble Aβ42 level was significantly higher in PDND and PDD than controls in all regions, and in the midfrontal and cingulate cortex, it was significantly higher in PDD than DLB. In DLB the level of soluble Aβ42 was significantly higher than in controls and PDND in the parahippocampus and higher than controls in the thalamus. The soluble Aβ40 level was significantly elevated in PDND and PDD compared with controls in all regions. The level was also significantly higher in DLB than in controls in all regions except the cingulate cortex. Soluble total α-syn levels were significantly greater in PDND than controls in all regions, and significantly higher in PDD than controls in the midfrontal cortex, parahippocampus and thalamus. *P <0.05, **P <0.01, ***P <0.001. Aβ, amyloid-β; DLB, dementia with Lewy bodies; PDD, Parkinson’s disease with dementia; PDND, Parkinson’s disease without dementia; α-syn, α-synuclein.

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