Figure 1

Correlation between Aβ and insoluble pSer129 α-syn. Each point represents a separate case. The best-fit linear regression (solid lines) and 95% confidence intervals (interrupted lines) are superimposed. Only significant P-values (and associated correlation coefficients) are shown in the figure. Significant positive correlations between insoluble pSer129 α-syn and soluble Aβ42/Aβ40 were found in the parahippocampal (PH) cortex and thalamus (TH). Significant positive correlations were also found between insoluble pSer129 α-syn and insoluble Aβ42 in the cingulate (CG) and PH cortex. In addition, significant correlations were found between insoluble pSer129 α-syn and insoluble Aβ40 in the midfrontal and CG cortex. Aβ, amyloid-β; pSer129 α-syn, alpha-synuclein phosphorylated at serine 129.