Table 1 Sumary of neuropathologic, clinical, imaging and fluid markers in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease
From: Biomarkers in biological fluids for dementia with Lewy bodies
AD | AD and DLB | DLB | DLB and PD(D) | PD | |
|---|---|---|---|---|---|
Neuropathology | Neurofibrillary tangles | Lewy bodies | |||
Amyloid plaques | |||||
Clinical symptoms | Cognitive decline | Spontaneous hallucinations | Cognitive decline | ||
RBD | |||||
L-Dopa response | |||||
Nuclear imaging | PIB binding↑ | DAT↚ | |||
CSF biomarkers | tau ↑ | β-Amyloid 1-42 ↚ | β-Amyloid 1-40ox↑ | β-synucleinv | ±-Synuclein↚ |
p-tau ↑ | Soluble NG2↚ | CART↚ | Neurosin↚ | Oligomeric β-synuclein↑ | |
NF? | |||||
Serum biomarkers | H-FABP ↑ | ||||
Ca/Mg↑ |