PLD3 is accumulated on neuritic plaques in Alzheimer’s disease brains

Table 1 Demographic profile of the cases examined in the present study

Case number	IHC	qPCR/WB	Cause of death	Brain weight (g)	Postmortem interval (hours)	Braak staging (amyloid deposition/neurofibrillary degeneration)	p.V232M variant	c.1326GTable A variant
NC1	+	+	Acute myocardial infarction	1,130	1.4	A/II	V/V	G/G
NC2	+	+	Acute myocardial infarction	1,350	1.6	0/II	V/V	G/G
NC3	+	+	Lung cancer	1,060	3.9	A/II	V/V	G/G
NC4	+	+	Dissecting aortic aneurysm	1,400	4.8	A/I	V/V	G/G
AD1	+	+	Pneumonia	1,000	1.1	C/VI	V/V	G/G
AD2	+	+	Pneumonia	1,230	14	C/VI	V/V	G/G
AD3	+	+	Pneumonia	1,220	10.5	C/VI	V/V	G/G
AD4	+	+	Pneumonia	1,240	8.1	C/VI	V/V	G/G
AD5	ND	+	Lung cancer	1,090	4.5	C/VI	V/V	G/G
AD6	+	+	Pulmonary infarction	840	3	C/VI	V/V	G/G
AD7	ND	+	Respiratory failure by aspiration	1,200	3.8	B/IV	V/V	G/G
AD8	+	ND	Pneumonia	1,060	8	C/VI	ND	ND
AD9	+	ND	Pneumonia	970	NA	C/VI	ND	ND
AD10	+	ND	Pneumonia	870	1	C/VI	ND	ND
AD11	+	ND	Lung cancer	1,125	14.5	C/VI	ND	ND
AD12	+	ND	Multiple organ failure	775	13	C/VI	ND	ND
PD1	ND	+	Pneumonia	1,330	9.5	B/IV	V/V	G/G
PD2	+	+	Pneumonia	1,130	2.5	B/II	V/V	G/G
PD3	+	+	Respiratory failure by aspiration	910	2.5	B/II	V/V	G/G
PD4	ND	+	Colon cancer	1,430	4	A/I	V/V	G/G
PD5	+	ND	Pneumonia	1,320	9.3	C/III	ND	ND
ALS1	+	+	Respiratory failure	1,480	10.5	0/0	V/V	G/G
ALS2	+	+	Respiratory failure	1,090	1.3	0/I	V/V	G/G
ALS3	+	+	Respiratory failure	1,560	3	0/I	V/V	G/G
ALS4	+	+	Respiratory failure	1,320	10	0/II	V/V	G/G
ALS5	ND	+	Respiratory failure	1,360	2.5	B/I	V/V	G/G
ALS6	ND	+	Respiratory failure	1,600	13	B/I	V/V	G/G
MSA1	+	ND	Pneumonia, septicemia	1,040	1.5	0/I	ND	ND
MSA2	+	ND	Pneumonia	1,090	12	A/I	ND	ND

Demographic profile of thGenotyping analysise cases processed for immunohistochemistry (IHC), quantitative reverse transcription-polymerase chain reaction (qPCR), and western blot (WB) is shown with the case number, the cause of death, brain weight, the postmortem interval, the Braak Staging (amyloid deposition/neurofibrillary degeneration), p.Val232Met variant of rs145999145, and c.1326GTable A variant of rs4819. AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; MSA, multiple system atrophy; NA, information not available; NC, non-neurological causes; ND, not determined; PD, Parkinson’s disease.

ISSN: 1758-9193