|
Subjects with CUPS: subgroup
|
Ioflupane [123I] imaging vs. 1-year clinical diagnosis as reference standard
|
Baseline clinical diagnosis vs. 1-year clinical diagnosis as reference standard
|
Pvaluea
|
|---|
| | |
Result
|
Exact 95% CI
|
Result
|
Exact 95% CI
| |
|---|
|
Subgroup A: BRP dominant
b
|
Sensitivity
c
|
0.8947
|
(0.6686, 0.9870)
|
1.0000
|
(0.8389, 1.0000)
|
0.2192
|
| |
Specificity
d
|
0.6667
|
(0.2228, 0.9567)
|
0.3330
|
(0.0433, 0.7772)
|
0.5671
|
| |
Accuracy
|
0.8400
|
(0.6392, 0.9546)
|
0.8519
|
(0.6627, 0.9581)
|
1.0000
|
| |
PPV
|
0.8947
|
(0.6686, 0.9870)
|
0.8400
|
(0.6392, 0.9546)
|
0.6843
|
| |
NPV
|
0.6667
|
(0.2228, 0.9567)
|
1.0000
|
(0.1581, 1.0000)
|
1.0000
|
|
Subgroup B: TD
e
| | | | | | |
|
Sensitivity
c
|
1.0000
|
(0.6915, 1.0000)
|
0.8889
|
(0.5175, 0.9972)
|
0.4737
|
|
Specificity
d
|
1.0000
|
(0.8628, 1.0000)
|
0.5652
|
(0.3449, 0.7681)
|
<0.0001
|
|
Accuracy
|
1.0000
|
(0.9000, 1.0000)
|
0.6563
|
(0.4681, 0.8143)
|
<0.0001
|
|
PPV
|
1.0000
|
(0.6915, 1.0000)
|
0.4444
|
(0.2153, 0.6924)
|
0.0039
|
|
NPV
|
1.0000
|
(0.8628, 1.0000)
|
0.9286
|
(0.6613, 0.9982)
|
0.3590
|
|
Subgroup C: balanced
f
| | | | | | |
|
Sensitivity
c
|
0.9500
|
(0.7513, 0.9987)
|
0.8500
|
(0.6211, 0.9679)
|
0.6050
|
|
Specificity
d
|
1.0000
|
(0.7354, 1.0000)
|
0.5385
|
(0.2513, 0.8078)
|
0.0149
|
|
Accuracy
|
0.9688
|
(0.8378, 0.9992)
|
0.7273
|
(0.5448, 0.8670)
|
0.0129
|
|
PPV
|
1.0000
|
(0.8235, 1.0000)
|
0.7391
|
(0.5159, 0.8977)
|
0.0244
|
|
NPV
|
0.9231
|
0.6397, 0.9981)
|
0.7000
|
(0.3475, 0.9333)
|
0.2806
|
- BRP, bradykinesia, rigidity, postural instability; CI, confidence interval; CUPS, clinically uncertain parkinsonian syndrome; NPV, negative predictive value; PPV, positive predictive values; TD, tremor dominant. a
P value is based on Fisher’s exact test. bMaximal score of bradykinesia, rigidity, or postural instability > tremor score. cTremor score > maximal score of bradykinesia, rigidity, or postural instability. dMaximal score of bradykinesia, rigidity, or postural instability = tremor score. eSensitivity is equivalent to positive percent agreement. fSpecificity is equivalent to negative percent agreement.
