Subjects with CUPS: subgroup | Ioflupane [123I] imaging vs. 1-year clinical diagnosis as reference standard | Baseline clinical diagnosis vs. 1-year clinical diagnosis as reference standard | Pvaluea | |||
---|---|---|---|---|---|---|
Result | Exact 95% CI | Result | Exact 95% CI | |||
Subgroup A: BRP dominant b | Sensitivity c | 0.8947 | (0.6686, 0.9870) | 1.0000 | (0.8389, 1.0000) | 0.2192 |
Specificity d | 0.6667 | (0.2228, 0.9567) | 0.3330 | (0.0433, 0.7772) | 0.5671 | |
Accuracy | 0.8400 | (0.6392, 0.9546) | 0.8519 | (0.6627, 0.9581) | 1.0000 | |
PPV | 0.8947 | (0.6686, 0.9870) | 0.8400 | (0.6392, 0.9546) | 0.6843 | |
NPV | 0.6667 | (0.2228, 0.9567) | 1.0000 | (0.1581, 1.0000) | 1.0000 | |
Subgroup B: TD e | ||||||
Sensitivity c | 1.0000 | (0.6915, 1.0000) | 0.8889 | (0.5175, 0.9972) | 0.4737 | |
Specificity d | 1.0000 | (0.8628, 1.0000) | 0.5652 | (0.3449, 0.7681) | <0.0001 | |
Accuracy | 1.0000 | (0.9000, 1.0000) | 0.6563 | (0.4681, 0.8143) | <0.0001 | |
PPV | 1.0000 | (0.6915, 1.0000) | 0.4444 | (0.2153, 0.6924) | 0.0039 | |
NPV | 1.0000 | (0.8628, 1.0000) | 0.9286 | (0.6613, 0.9982) | 0.3590 | |
Subgroup C: balanced f | ||||||
Sensitivity c | 0.9500 | (0.7513, 0.9987) | 0.8500 | (0.6211, 0.9679) | 0.6050 | |
Specificity d | 1.0000 | (0.7354, 1.0000) | 0.5385 | (0.2513, 0.8078) | 0.0149 | |
Accuracy | 0.9688 | (0.8378, 0.9992) | 0.7273 | (0.5448, 0.8670) | 0.0129 | |
PPV | 1.0000 | (0.8235, 1.0000) | 0.7391 | (0.5159, 0.8977) | 0.0244 | |
NPV | 0.9231 | 0.6397, 0.9981) | 0.7000 | (0.3475, 0.9333) | 0.2806 |