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Table 7 Comparison: diagnostic performance of ioflupane [ 123 I] imaging with baseline clinical diagnosis (clinical syndrome predominance, n = 92)

From: Association between Hoehn and Yahr, Mini-Mental State Examination, age, and clinical syndrome predominance and diagnostic effectiveness of ioflupane I 123 injection (DaTSCANTM) in subjects with clinically uncertain parkinsonian syndromes

Subjects with CUPS: subgroup Ioflupane [123I] imaging vs. 1-year clinical diagnosis as reference standard Baseline clinical diagnosis vs. 1-year clinical diagnosis as reference standard Pvaluea
   Result Exact 95% CI Result Exact 95% CI  
Subgroup A: BRP dominant b Sensitivity c 0.8947 (0.6686, 0.9870) 1.0000 (0.8389, 1.0000) 0.2192
  Specificity d 0.6667 (0.2228, 0.9567) 0.3330 (0.0433, 0.7772) 0.5671
  Accuracy 0.8400 (0.6392, 0.9546) 0.8519 (0.6627, 0.9581) 1.0000
  PPV 0.8947 (0.6686, 0.9870) 0.8400 (0.6392, 0.9546) 0.6843
  NPV 0.6667 (0.2228, 0.9567) 1.0000 (0.1581, 1.0000) 1.0000
Subgroup B: TD e       
Sensitivity c 1.0000 (0.6915, 1.0000) 0.8889 (0.5175, 0.9972) 0.4737
Specificity d 1.0000 (0.8628, 1.0000) 0.5652 (0.3449, 0.7681) <0.0001
Accuracy 1.0000 (0.9000, 1.0000) 0.6563 (0.4681, 0.8143) <0.0001
PPV 1.0000 (0.6915, 1.0000) 0.4444 (0.2153, 0.6924) 0.0039
NPV 1.0000 (0.8628, 1.0000) 0.9286 (0.6613, 0.9982) 0.3590
Subgroup C: balanced f       
Sensitivity c 0.9500 (0.7513, 0.9987) 0.8500 (0.6211, 0.9679) 0.6050
Specificity d 1.0000 (0.7354, 1.0000) 0.5385 (0.2513, 0.8078) 0.0149
Accuracy 0.9688 (0.8378, 0.9992) 0.7273 (0.5448, 0.8670) 0.0129
PPV 1.0000 (0.8235, 1.0000) 0.7391 (0.5159, 0.8977) 0.0244
NPV 0.9231 0.6397, 0.9981) 0.7000 (0.3475, 0.9333) 0.2806
  1. BRP, bradykinesia, rigidity, postural instability; CI, confidence interval; CUPS, clinically uncertain parkinsonian syndrome; NPV, negative predictive value; PPV, positive predictive values; TD, tremor dominant. a P value is based on Fisher’s exact test. bMaximal score of bradykinesia, rigidity, or postural instability > tremor score. cTremor score > maximal score of bradykinesia, rigidity, or postural instability. dMaximal score of bradykinesia, rigidity, or postural instability = tremor score. eSensitivity is equivalent to positive percent agreement. fSpecificity is equivalent to negative percent agreement.