Skip to main content

Table 7 Comparison: diagnostic performance of ioflupane [ 123 I] imaging with baseline clinical diagnosis (clinical syndrome predominance, n = 92)

From: Association between Hoehn and Yahr, Mini-Mental State Examination, age, and clinical syndrome predominance and diagnostic effectiveness of ioflupane I 123 injection (DaTSCANTM) in subjects with clinically uncertain parkinsonian syndromes

Subjects with CUPS: subgroup

Ioflupane [123I] imaging vs. 1-year clinical diagnosis as reference standard

Baseline clinical diagnosis vs. 1-year clinical diagnosis as reference standard

Pvaluea

  

Result

Exact 95% CI

Result

Exact 95% CI

 

Subgroup A: BRP dominant b

Sensitivity c

0.8947

(0.6686, 0.9870)

1.0000

(0.8389, 1.0000)

0.2192

 

Specificity d

0.6667

(0.2228, 0.9567)

0.3330

(0.0433, 0.7772)

0.5671

 

Accuracy

0.8400

(0.6392, 0.9546)

0.8519

(0.6627, 0.9581)

1.0000

 

PPV

0.8947

(0.6686, 0.9870)

0.8400

(0.6392, 0.9546)

0.6843

 

NPV

0.6667

(0.2228, 0.9567)

1.0000

(0.1581, 1.0000)

1.0000

Subgroup B: TD e

      

Sensitivity c

1.0000

(0.6915, 1.0000)

0.8889

(0.5175, 0.9972)

0.4737

Specificity d

1.0000

(0.8628, 1.0000)

0.5652

(0.3449, 0.7681)

<0.0001

Accuracy

1.0000

(0.9000, 1.0000)

0.6563

(0.4681, 0.8143)

<0.0001

PPV

1.0000

(0.6915, 1.0000)

0.4444

(0.2153, 0.6924)

0.0039

NPV

1.0000

(0.8628, 1.0000)

0.9286

(0.6613, 0.9982)

0.3590

Subgroup C: balanced f

      

Sensitivity c

0.9500

(0.7513, 0.9987)

0.8500

(0.6211, 0.9679)

0.6050

Specificity d

1.0000

(0.7354, 1.0000)

0.5385

(0.2513, 0.8078)

0.0149

Accuracy

0.9688

(0.8378, 0.9992)

0.7273

(0.5448, 0.8670)

0.0129

PPV

1.0000

(0.8235, 1.0000)

0.7391

(0.5159, 0.8977)

0.0244

NPV

0.9231

0.6397, 0.9981)

0.7000

(0.3475, 0.9333)

0.2806

  1. BRP, bradykinesia, rigidity, postural instability; CI, confidence interval; CUPS, clinically uncertain parkinsonian syndrome; NPV, negative predictive value; PPV, positive predictive values; TD, tremor dominant. a P value is based on Fisher’s exact test. bMaximal score of bradykinesia, rigidity, or postural instability > tremor score. cTremor score > maximal score of bradykinesia, rigidity, or postural instability. dMaximal score of bradykinesia, rigidity, or postural instability = tremor score. eSensitivity is equivalent to positive percent agreement. fSpecificity is equivalent to negative percent agreement.