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Table 6 Efficacy: baseline clinical diagnosis, prediction of clinical diagnosis 1 year post scan (clinical syndrome predominance, n = 92)

From: Association between Hoehn and Yahr, Mini-Mental State Examination, age, and clinical syndrome predominance and diagnostic effectiveness of ioflupane I 123 injection (DaTSCANTM) in subjects with clinically uncertain parkinsonian syndromes

Subjects with CUPS Clinical diagnosis at 1 year post-scan
Subgroup A: BRP dominanta Subgroup B: TDb Subgroup C: balancedc
Baseline clinical diagnosis PS Non-PS Total PS Non-PS Total PS Non-PS Total
Positive (PS) 21 4 25 8 10 18 17 6 23
Negative (non-PS) 0 2 2 1 13 14 3 7 10
Total 21 6 27 9 23 32 20 13 33
Statistic Result Exact 95% CI P value d (subgroup A vs. subgroup B) Result Exact 95% CI P value d (subgroup B vs. subgroup C) Result Exact 95% CI P value d (subgroup C vs. subgroup A)
Sensitivity e 1.0000 (0.8389, 1.0000) 0.3000 0.8889 (0.5175, 0.9972) 1.0000 0.8500 (0.6211, 0.9679) 0.1069
Specificity f 0.3330 (0.0433, 0.7772) 0.3898 0.5652 (0.3449, 0.7681) 1.0000 0.5385 (0.2513, 0.8078) 0.6285
Accuracy 0.8519 (0.6627, 0.9581) 0.1335 0.6563 (0.4681, 0.8143) 0.5977 0.7273 (0.5448, 0.8670) 0.3480
Positive predictive value 0.8400 (0.6392, 0.9546) 0.0093 0.4444 (0.2153, 0.6924) 0.1055 0.7391 (0.5159, 0.8977) 0.4869
Negative predictive value 1.0000 (0.1581, 1.0000) 1.0000 0.9286 (0.6613, 0.9982) 0.2721 0.7000 (0.3475, 0.9333) 1.0000
  1. Scores for motor signs were 1 for none, 2 for possible, and 3 for definite. Excluded were subjects with 1-year clinical diagnosis of inconclusive, subjects with missing ioflupane [123I] imaging result, or subjects with missing 1-year clinical diagnosis. BRP, bradykinesia, rigidity, postural instability; CI, confidence interval; CUPS, clinically uncertain parkinsonian syndrome; PS, Parkinsonian syndrome; TD, tremor dominant. aMaximal score of bradykinesia, rigidity, or postural instability > tremor score. bTremor score > maximal score of bradykinesia, rigidity, or postural instability. c:Maximal score of bradykinesia, rigidity, or postural instability = tremor score. d P value is based on Fisher’s exact test. eSensitivity is equivalent to positive percent agreement. fSpecificity is equivalent to negative percent agreement.