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Table 6 Efficacy: baseline clinical diagnosis, prediction of clinical diagnosis 1 year post scan (clinical syndrome predominance, n = 92)

From: Association between Hoehn and Yahr, Mini-Mental State Examination, age, and clinical syndrome predominance and diagnostic effectiveness of ioflupane I 123 injection (DaTSCANTM) in subjects with clinically uncertain parkinsonian syndromes

Subjects with CUPS

Clinical diagnosis at 1 year post-scan

Subgroup A: BRP dominanta

Subgroup B: TDb

Subgroup C: balancedc

Baseline clinical diagnosis

PS

Non-PS

Total

PS

Non-PS

Total

PS

Non-PS

Total

Positive (PS)

21

4

25

8

10

18

17

6

23

Negative (non-PS)

0

2

2

1

13

14

3

7

10

Total

21

6

27

9

23

32

20

13

33

Statistic

Result

Exact 95% CI

P value d (subgroup A vs. subgroup B)

Result

Exact 95% CI

P value d (subgroup B vs. subgroup C)

Result

Exact 95% CI

P value d (subgroup C vs. subgroup A)

Sensitivity e

1.0000

(0.8389, 1.0000)

0.3000

0.8889

(0.5175, 0.9972)

1.0000

0.8500

(0.6211, 0.9679)

0.1069

Specificity f

0.3330

(0.0433, 0.7772)

0.3898

0.5652

(0.3449, 0.7681)

1.0000

0.5385

(0.2513, 0.8078)

0.6285

Accuracy

0.8519

(0.6627, 0.9581)

0.1335

0.6563

(0.4681, 0.8143)

0.5977

0.7273

(0.5448, 0.8670)

0.3480

Positive predictive value

0.8400

(0.6392, 0.9546)

0.0093

0.4444

(0.2153, 0.6924)

0.1055

0.7391

(0.5159, 0.8977)

0.4869

Negative predictive value

1.0000

(0.1581, 1.0000)

1.0000

0.9286

(0.6613, 0.9982)

0.2721

0.7000

(0.3475, 0.9333)

1.0000

  1. Scores for motor signs were 1 for none, 2 for possible, and 3 for definite. Excluded were subjects with 1-year clinical diagnosis of inconclusive, subjects with missing ioflupane [123I] imaging result, or subjects with missing 1-year clinical diagnosis. BRP, bradykinesia, rigidity, postural instability; CI, confidence interval; CUPS, clinically uncertain parkinsonian syndrome; PS, Parkinsonian syndrome; TD, tremor dominant. aMaximal score of bradykinesia, rigidity, or postural instability > tremor score. bTremor score > maximal score of bradykinesia, rigidity, or postural instability. c:Maximal score of bradykinesia, rigidity, or postural instability = tremor score. d P value is based on Fisher’s exact test. eSensitivity is equivalent to positive percent agreement. fSpecificity is equivalent to negative percent agreement.