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Table 5 Efficacy parameters for prediction of ioflupane [ 123 I] imaging, 1 year post scan: clinical syndrome predominance ( n = 92)

From: Association between Hoehn and Yahr, Mini-Mental State Examination, age, and clinical syndrome predominance and diagnostic effectiveness of ioflupane I 123 injection (DaTSCANTM) in subjects with clinically uncertain parkinsonian syndromes

Subjects with CUPS Clinical diagnosis at 1 year post-scan   
Subgroup A: BRP dominanta Subgroup B: TDb Subgroup C: balancedc
PS Non-PS Total PS Non-PS Total PS Non-PS Total
Abnormal ioflupane [ 123 I] images d 17 2 19 10 0 10 19 0 19
Normal ioflupane [ 123 I] images 2 4 6 0 25 25 1 12 13
Total 19 6 25 10 25 35 20 12 32
Statistic Result Exact 95% CI P value e (subgroup A vs. subgroup B) Result Exact 95% CI P value e (subgroup B vs. subgroup C) Result Exact 95% CI P value e (subgroup C vs. subgroup A)
Sensitivity f 0.8947 (0.6686, 0.9870) 0.5320 1.0000 (0.6915, 1.0000) 1.0000 0.9500 (0.7513, 0.9987) 0.6050
Specificity g 0.6667 (0.2228, 0.9567) 0.0323 1.0000 (0.8628, 1.0000) NE 1.0000 (0.7354, 1.0000) 0.0980
Accuracy 0.8400 (0.6392, 0.9546) 0.0259 1.0000 (0.9000, 1.0000) 0.4776 0.9688 (0.8378, 0.9992) 0.1575
Positive predictive value 0.8947 (0.6686, 0.9870) 0.5320 1.0000 (0.6915, 1.0000) NE 1.0000 (0.8235, 1.0000) 0.4865
Negative predictive value 0.6667 (0.2228, 0.9567) 0.0323 1.0000 (0.8628, 1.0000) 0.3421 0.9231 0.6397, 0.9981) 0.2219
  1. BRP, bradykinesia, rigidity, postural instability; CI, confidence interval; CUPS, clinically uncertain parkinsonian syndrome; NE, not estimable; PS: Parkinsonian syndrome; TD, tremor dominant. aMaximal score of bradykinesia, rigidity, or postural instability > tremor score. bTremor score > maximal score of bradykinesia, rigidity, or postural instability. cMaximal score of bradykinesia, rigidity, or postural instability = tremor score. dAbnormal imaging types 1, 2 and 3. e P value is based on Fisher’s exact test. fSensitivity is equivalent to positive percent agreement. gSpecificity is equivalent to negative percent agreement.