Association between Hoehn and Yahr, Mini-Mental State Examination, age, and clinical syndrome predominance and diagnostic effectiveness of ioflupane I 123 injection (DaTSCANTM) in subjects with clinically uncertain parkinsonian syndromes

Table 4 Efficacy parameters for prediction of clinical diagnosis 1 year post scan: subject’s baseline age ( n = 92)

Subjects with CUPS	Clinical diagnosis at 1 year post-scan
	Subgroup: <68 years of age			Subgroup: ≥68 years of age
	PS	Non-PS	Total	PS	Non-PS	Total
Abnormal ioflupane [ ¹²³ I] images ^a	22	0	22	24	2	26
Normal ioflupane [ ¹²³ I] images	2	20	22	1	21	22
Total	24	20	44	25	23	48
Statistic	Result	Exact 95% CI		Result	Exact 95% CI	P value/analysis method ^b
Sensitivity ^c	0.9167	(0.7300, 0.9897)		0.9600	(0.7965, 0.9990)	0.6092
Specificity ^d	1.0000	(0.8316, 1.0000)		0.9130	(0.7196, 0.9893)	0.4906
Accuracy	0.9545	(0.8453, 0.9944)		0.9375	(0.8280, 0.9869)	1.0000
Positive predictive value	1.0000	(0.8456, 1.0000)		0.9231	(0.7487, 0.9905)	0.4929
Negative predictive value	0.9091	(0.7084, 0.9888)		0.9545	(0.7716, 0.9988)	1.0000

CI, confidence interval; CUPS, clinically uncertain parkinsonian syndrome; PS, parkinsonian syndrome. ^aAbnormal imaging types 1, 2 and 3. ^b P value is based on Fisher’s exact test. ^cSensitivity is equivalent to positive percent agreement. ^dSpecificity is equivalent to negative percent agreement.

ISSN: 1758-9193