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Table 4 Efficacy parameters for prediction of clinical diagnosis 1 year post scan: subject’s baseline age ( n = 92)

From: Association between Hoehn and Yahr, Mini-Mental State Examination, age, and clinical syndrome predominance and diagnostic effectiveness of ioflupane I 123 injection (DaTSCANTM) in subjects with clinically uncertain parkinsonian syndromes

Subjects with CUPS

Clinical diagnosis at 1 year post-scan

Subgroup: <68 years of age

Subgroup: ≥68 years of age

PS

Non-PS

Total

PS

Non-PS

Total

Abnormal ioflupane [ 123 I] images a

22

0

22

24

2

26

Normal ioflupane [ 123 I] images

2

20

22

1

21

22

Total

24

20

44

25

23

48

Statistic

Result

Exact 95% CI

 

Result

Exact 95% CI

P value/analysis method b

Sensitivity c

0.9167

(0.7300, 0.9897)

 

0.9600

(0.7965, 0.9990)

0.6092

Specificity d

1.0000

(0.8316, 1.0000)

 

0.9130

(0.7196, 0.9893)

0.4906

Accuracy

0.9545

(0.8453, 0.9944)

 

0.9375

(0.8280, 0.9869)

1.0000

Positive predictive value

1.0000

(0.8456, 1.0000)

 

0.9231

(0.7487, 0.9905)

0.4929

Negative predictive value

0.9091

(0.7084, 0.9888)

 

0.9545

(0.7716, 0.9988)

1.0000

  1. CI, confidence interval; CUPS, clinically uncertain parkinsonian syndrome; PS, parkinsonian syndrome. aAbnormal imaging types 1, 2 and 3. b P value is based on Fisher’s exact test. cSensitivity is equivalent to positive percent agreement. dSpecificity is equivalent to negative percent agreement.