Comorbidity profile in dementia with Lewy bodies versus Alzheimer’s disease: a linkage study between the Swedish Dementia Registry and the Swedish National Patient Registry

Table 4 Comorbidity profile of the patients with dementia with Lewy bodies versus Alzheimer’s disease patients based on the Royal College of Surgeons Charlson Score indicating International Classification of Disease, 10th revision codes for 14 disease categories

Disease category	DLB	AD	Unadjusted	Pvalue^a	Adjusted	Pvalue^b
Disease category	(n=634)	(n=9,161)	OR (95% CI)	Pvalue^a	OR (95%CI)	Pvalue^b
Myocardial infarction	34 (5.4)	532 (5.8)	0.92 (0.64 to 1.31)	0.643	0.85 (0.59 to 1.22)	0.372
Congestive cardiac failure	38 (6.0)	458 (5.0)	1.21 (0.86 to 1.70)	0.270	1.21 (0.85 to 1.73)	0.282
Peripheral vascular disease	15 (2.4)	271 (3.0)	0.79 (0.47 to 1.34)	0.392	0.77 (0.45 to 1.31)	0.335
Cerebrovascular disease	103 (16.2)	912 (10.0)	1.75 (1.40 to 2.19)	<0.001	1.74 (1.38 to 2.19)	<0.001
Chronic pulmonary disease	27 (4.3)	480 (5.2)	0.80 (0.54 to 1.20)	0.281	0.88 (0.59 to 1.31)	0.525
Rheumatological disease	12 (1.9)	286 (3.1)	0.60 (0.33 to 1.07)	0.081	0.64 (0.35 to 1.19)	0.160
Liver disease	4 (0.6)	48 (0.5)	1.20 (0.43 to 3.35)	0.578	1.13 (0.40 to 3.19)	0.818
Diabetes mellitus	26 (4.1)	481 (5.3)	0.77 (0.52 to 1.15)	0.206	0.73 (0.48 to 1.11)	0.145
Hemiplegia or paraplegia	0	19 (0.2)	–	0.631	–	0.998
Renal disease	11 (1.7)	98 (1.1)	1.63 (0.87 to 3.06)	0.123	1.57 (0.83 to 2.97)	0.167
Any malignancy	94 (14.8)	1283 (14.0)	1.07 (0.85 to 1.34)	0.565	0.96 (0.75 to 1.21)	0.707
Metastatic solid tumor	2 (0.3)	74 (0.8)	0.39 (0.09 to 1.59)	0.239	0.42 (0.10 to 1.74)	0.235
AIDS/HIV infection	0	1 (0.0)	–	–	–	–
Total Charlson score	1.52 (0.85)	1.33 (0.89)	1.25 (1.15 to 1.36)	<0.001	1.22 (1.12 to 1.33)	<0.001

Data presented as mean (standard deviation). Adjustment is made for age, sex, and Mini-Mental State Examination score. The AD group is considered the reference group. The dementia category of the original Charlson scoring is not reported here because the whole study population is dementia patients in our study. Statistically significant ORs (P≤0.05) in bold. AD, Alzheimer’s disease; CI, confidence interval; DLB, dementia with Lewy bodies; OR, odds ratio. ^aChi-square statistics. ^bBinary logistic regression model.

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